Detection and quantification of Plasmodium falciparum in human blood by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: a proof of concept study

• Published in: Malaria journal Vol. 22; no. 1; pp. 1 - 10
• Main Authors: Stauning, Marius Ahm, Jensen, Christian Salgård, Staalsøe, Trine, Kurtzhals, Jørgen A. L.
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 26.09.2023; BioMed Central; BMC
• Subjects: Analysis; Antigens; Automation; Blood cells; Blood groups; Control; Desorption; Detection; Diagnosis; Diagnostics; Erythrocytes; Flight; Human diseases; Identification and classification; Ionization; Lasers; Malaria; Mass spectra; Mass spectrometry; Mass spectroscopy; Medical screening; Microbiological strains; Microscopy; Parasites; Plasmodium falciparum; Prevention; Risk factors; Saponins; Scientific imaging; Strains (organisms); Testing; Time-of-flight mass spectrometry; Vector-borne diseases; Denmark; United States > US; Germany

Background Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) has revolutionized identification of bacteria and is becoming available in an increasing number of laboratories in malaria-endemic countries. The purpose of this proof-of-concept study was to explore...