Serum dysregulation of serine and glycine metabolism as predictive biomarker for cognitive decline in frail elderly subjects

• Published in: Translational psychiatry Vol. 14; no. 1; pp. 281 - 13
• Main Authors: Imarisio, Alberto, Yahyavi, Isar, Gasparri, Clara, Hassan, Amber, Avenali, Micol, Di Maio, Anna, Buongarzone, Gabriele, Galandra, Caterina, Picascia, Marta, Filosa, Asia, Monti, Maria Cristina, Pacchetti, Claudio, Errico, Francesco, Rondanelli, Mariangela, Usiello, Alessandro, Valente, Enza Maria
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.07.2024; Nature Publishing Group
• Subjects: 631/378/1595/2167; 631/378/340; 692/53/2421; 692/53/2422; 692/699/476/1414; 82/16; Aged; Aged, 80 and over; Amino acids; Behavioral Sciences; Biological Psychology; Biomarkers; Biomarkers - blood; Cognitive Dysfunction - blood; Female; Frail Elderly; Frailty; Frailty - blood; Glycine - blood; Homeostasis; Humans; Male; Medicine; Medicine & Public Health; Metabolism; Neurosciences; Pharmacotherapy; Psychiatry; Serine - blood

Frailty is a common age-related clinical syndrome characterized by a decline in the function of multiple organ systems, increased vulnerability to stressors, and a huge socio-economic burden. Despite recent research efforts, the physiopathological mechanisms underlying frailty remain elusive and bio...