Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera

• Published in: Nature communications Vol. 14; no. 1; pp. 6195 - 11
• Main Authors: Hutchinson, Geoffrey B., Abiona, Olubukola M., Ziwawo, Cynthia T., Werner, Anne P., Ellis, Daniel, Tsybovsky, Yaroslav, Leist, Sarah R., Palandjian, Charis, West, Ande, Fritch, Ethan J., Wang, Nianshuang, Wrapp, Daniel, Boyoglu-Barnum, Seyhan, Ueda, George, Baker, David, Kanekiyo, Masaru, McLellan, Jason S., Baric, Ralph S., King, Neil P., Graham, Barney S., Corbett-Helaire, Kizzmekia S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 101/28; 631/250/590/2294; 631/326/596/2078; 631/326/596/4130; 631/61/24/590/2294; 631/61/338/469; 64; 64/60; 96/1; 96/106; Animals; Antibodies; Antibodies, Neutralizing; Antibodies, Viral; Antibody Formation; Antibody response; Antigens; Coronaviridae; Coronaviruses; COVID-19; Epitopes; Epitopes - metabolism; Female; Females; Humanities and Social Sciences; Immunogenicity; Male; Mice; Middle East respiratory syndrome; Middle East Respiratory Syndrome Coronavirus; multidisciplinary; Nanoparticles; Proteins; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus; Trimers; Vaccines; Viral diseases

Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notably mutable viruses. In coronaviruses, this work is predomina...