Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera
Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notably mutable viruses. In coronaviruses, this work is predomina...
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| Published in | Nature communications Vol. 14; no. 1; pp. 6195 - 11 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
04.10.2023
Nature Publishing Group Nature Portfolio |
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| Online Access | Get full text |
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| Abstract | Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notably mutable viruses. In coronaviruses, this work is predominantly aimed at targeting conserved epitopes of the receptor binding domain. However, targeting conserved non-RBD epitopes could limit the potential for antigenic escape. To explore new potential targets, we engineered protein nanoparticles displaying coronavirus prefusion-stabilized spike (CoV_S-2P) trimers derived from MERS-CoV, SARS-CoV-1, SARS-CoV-2, hCoV-HKU1, and hCoV-OC43 and assessed their immunogenicity in female mice. Monotypic SARS-1 nanoparticles elicit cross-neutralizing antibodies against MERS-CoV and protect against MERS-CoV challenge. MERS and SARS nanoparticles elicit S1-focused antibodies, revealing a conserved site on the S N-terminal domain. Moreover, mosaic nanoparticles co-displaying distinct CoV_S-2P trimers elicit antibody responses to distant cross-group antigens and protect male and female mice against MERS-CoV challenge. Our findings will inform further efforts toward the development of pan-coronavirus vaccines.
Most current anti-coronavirus nanoparticle vaccines target epitopes within the RBD. Here, the authors developed nanoparticles displaying an array of spike fusion proteins derived from various coronaviruses and show that immunizing mice with these vaccines elicits broad and potent cross-reactive antibodies. |
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| AbstractList | Abstract Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notably mutable viruses. In coronaviruses, this work is predominantly aimed at targeting conserved epitopes of the receptor binding domain. However, targeting conserved non-RBD epitopes could limit the potential for antigenic escape. To explore new potential targets, we engineered protein nanoparticles displaying coronavirus prefusion-stabilized spike (CoV_S-2P) trimers derived from MERS-CoV, SARS-CoV-1, SARS-CoV-2, hCoV-HKU1, and hCoV-OC43 and assessed their immunogenicity in female mice. Monotypic SARS-1 nanoparticles elicit cross-neutralizing antibodies against MERS-CoV and protect against MERS-CoV challenge. MERS and SARS nanoparticles elicit S1-focused antibodies, revealing a conserved site on the S N-terminal domain. Moreover, mosaic nanoparticles co-displaying distinct CoV_S-2P trimers elicit antibody responses to distant cross-group antigens and protect male and female mice against MERS-CoV challenge. Our findings will inform further efforts toward the development of pan-coronavirus vaccines. Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notably mutable viruses. In coronaviruses, this work is predominantly aimed at targeting conserved epitopes of the receptor binding domain. However, targeting conserved non-RBD epitopes could limit the potential for antigenic escape. To explore new potential targets, we engineered protein nanoparticles displaying coronavirus prefusion-stabilized spike (CoV_S-2P) trimers derived from MERS-CoV, SARS-CoV-1, SARS-CoV-2, hCoV-HKU1, and hCoV-OC43 and assessed their immunogenicity in female mice. Monotypic SARS-1 nanoparticles elicit cross-neutralizing antibodies against MERS-CoV and protect against MERS-CoV challenge. MERS and SARS nanoparticles elicit S1-focused antibodies, revealing a conserved site on the S N-terminal domain. Moreover, mosaic nanoparticles co-displaying distinct CoV_S-2P trimers elicit antibody responses to distant cross-group antigens and protect male and female mice against MERS-CoV challenge. Our findings will inform further efforts toward the development of pan-coronavirus vaccines. Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notably mutable viruses. In coronaviruses, this work is predominantly aimed at targeting conserved epitopes of the receptor binding domain. However, targeting conserved non-RBD epitopes could limit the potential for antigenic escape. To explore new potential targets, we engineered protein nanoparticles displaying coronavirus prefusion-stabilized spike (CoV_S-2P) trimers derived from MERS-CoV, SARS-CoV-1, SARS-CoV-2, hCoV-HKU1, and hCoV-OC43 and assessed their immunogenicity in female mice. Monotypic SARS-1 nanoparticles elicit cross-neutralizing antibodies against MERS-CoV and protect against MERS-CoV challenge. MERS and SARS nanoparticles elicit S1-focused antibodies, revealing a conserved site on the S N-terminal domain. Moreover, mosaic nanoparticles co-displaying distinct CoV_S-2P trimers elicit antibody responses to distant cross-group antigens and protect male and female mice against MERS-CoV challenge. Our findings will inform further efforts toward the development of pan-coronavirus vaccines.Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notably mutable viruses. In coronaviruses, this work is predominantly aimed at targeting conserved epitopes of the receptor binding domain. However, targeting conserved non-RBD epitopes could limit the potential for antigenic escape. To explore new potential targets, we engineered protein nanoparticles displaying coronavirus prefusion-stabilized spike (CoV_S-2P) trimers derived from MERS-CoV, SARS-CoV-1, SARS-CoV-2, hCoV-HKU1, and hCoV-OC43 and assessed their immunogenicity in female mice. Monotypic SARS-1 nanoparticles elicit cross-neutralizing antibodies against MERS-CoV and protect against MERS-CoV challenge. MERS and SARS nanoparticles elicit S1-focused antibodies, revealing a conserved site on the S N-terminal domain. Moreover, mosaic nanoparticles co-displaying distinct CoV_S-2P trimers elicit antibody responses to distant cross-group antigens and protect male and female mice against MERS-CoV challenge. Our findings will inform further efforts toward the development of pan-coronavirus vaccines. Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notably mutable viruses. In coronaviruses, this work is predominantly aimed at targeting conserved epitopes of the receptor binding domain. However, targeting conserved non-RBD epitopes could limit the potential for antigenic escape. To explore new potential targets, we engineered protein nanoparticles displaying coronavirus prefusion-stabilized spike (CoV_S-2P) trimers derived from MERS-CoV, SARS-CoV-1, SARS-CoV-2, hCoV-HKU1, and hCoV-OC43 and assessed their immunogenicity in female mice. Monotypic SARS-1 nanoparticles elicit cross-neutralizing antibodies against MERS-CoV and protect against MERS-CoV challenge. MERS and SARS nanoparticles elicit S1-focused antibodies, revealing a conserved site on the S N-terminal domain. Moreover, mosaic nanoparticles co-displaying distinct CoV_S-2P trimers elicit antibody responses to distant cross-group antigens and protect male and female mice against MERS-CoV challenge. Our findings will inform further efforts toward the development of pan-coronavirus vaccines.Most current anti-coronavirus nanoparticle vaccines target epitopes within the RBD. Here, the authors developed nanoparticles displaying an array of spike fusion proteins derived from various coronaviruses and show that immunizing mice with these vaccines elicits broad and potent cross-reactive antibodies. Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer antibody-mediated immunity against divergent strains of notably mutable viruses. In coronaviruses, this work is predominantly aimed at targeting conserved epitopes of the receptor binding domain. However, targeting conserved non-RBD epitopes could limit the potential for antigenic escape. To explore new potential targets, we engineered protein nanoparticles displaying coronavirus prefusion-stabilized spike (CoV_S-2P) trimers derived from MERS-CoV, SARS-CoV-1, SARS-CoV-2, hCoV-HKU1, and hCoV-OC43 and assessed their immunogenicity in female mice. Monotypic SARS-1 nanoparticles elicit cross-neutralizing antibodies against MERS-CoV and protect against MERS-CoV challenge. MERS and SARS nanoparticles elicit S1-focused antibodies, revealing a conserved site on the S N-terminal domain. Moreover, mosaic nanoparticles co-displaying distinct CoV_S-2P trimers elicit antibody responses to distant cross-group antigens and protect male and female mice against MERS-CoV challenge. Our findings will inform further efforts toward the development of pan-coronavirus vaccines. Most current anti-coronavirus nanoparticle vaccines target epitopes within the RBD. Here, the authors developed nanoparticles displaying an array of spike fusion proteins derived from various coronaviruses and show that immunizing mice with these vaccines elicits broad and potent cross-reactive antibodies. |
| ArticleNumber | 6195 |
| Author | Kanekiyo, Masaru Baker, David Ziwawo, Cynthia T. Hutchinson, Geoffrey B. Boyoglu-Barnum, Seyhan Ellis, Daniel Tsybovsky, Yaroslav Corbett-Helaire, Kizzmekia S. King, Neil P. Wang, Nianshuang Abiona, Olubukola M. Werner, Anne P. Fritch, Ethan J. Wrapp, Daniel Palandjian, Charis Baric, Ralph S. West, Ande Graham, Barney S. McLellan, Jason S. Ueda, George Leist, Sarah R. |
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Chan School of Public Health – sequence: 9 givenname: Ande surname: West fullname: West, Ande organization: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill – sequence: 10 givenname: Ethan J. surname: Fritch fullname: Fritch, Ethan J. organization: Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill – sequence: 11 givenname: Nianshuang surname: Wang fullname: Wang, Nianshuang organization: College of Natural Sciences, University of Texas at Austin – sequence: 12 givenname: Daniel surname: Wrapp fullname: Wrapp, Daniel organization: College of Natural Sciences, University of Texas at Austin – sequence: 13 givenname: Seyhan surname: Boyoglu-Barnum fullname: Boyoglu-Barnum, Seyhan organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health – sequence: 14 givenname: George orcidid: 0000-0002-9792-7149 surname: Ueda fullname: Ueda, George organization: Institute for Protein Design, University of Washington School of Medicine, Department of Biochemistry, University of Washington School of Medicine – sequence: 15 givenname: David orcidid: 0000-0001-7896-6217 surname: Baker fullname: Baker, David organization: Institute for Protein Design, University of Washington School of Medicine, Department of Biochemistry, University of Washington School of Medicine, Howard Hughes Medical Institute, University of Washington – sequence: 16 givenname: Masaru orcidid: 0000-0001-5767-1532 surname: Kanekiyo fullname: Kanekiyo, Masaru organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health – sequence: 17 givenname: Jason S. orcidid: 0000-0003-3991-542X surname: McLellan fullname: McLellan, Jason S. organization: College of Natural Sciences, University of Texas at Austin – sequence: 18 givenname: Ralph S. orcidid: 0000-0001-6827-8701 surname: Baric fullname: Baric, Ralph S. organization: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill – sequence: 19 givenname: Neil P. orcidid: 0000-0002-2978-4692 surname: King fullname: King, Neil P. organization: Institute for Protein Design, University of Washington School of Medicine, Department of Biochemistry, University of Washington School of Medicine – sequence: 20 givenname: Barney S. surname: Graham fullname: Graham, Barney S. email: bgraham@msm.edu organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health – sequence: 21 givenname: Kizzmekia S. orcidid: 0000-0002-2641-4688 surname: Corbett-Helaire fullname: Corbett-Helaire, Kizzmekia S. email: kizzmekia_corbett@hsph.harvard.edu organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37794071$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1021_acsnano_4c07061 crossref_primary_10_3390_vaccines12010037 crossref_primary_10_3390_vetsci12020101 crossref_primary_10_1016_j_vaccine_2024_126700 crossref_primary_10_1016_j_it_2023_11_001 crossref_primary_10_3390_v17010001 crossref_primary_10_1016_j_celrep_2024_115036 crossref_primary_10_1038_s41467_024_45495_6 crossref_primary_10_1038_s41587_024_02486_8 crossref_primary_10_3389_fimmu_2024_1420216 crossref_primary_10_1371_journal_pone_0302243 |
| Cites_doi | 10.1126/science.abf6840 10.1016/j.celrep.2021.109929 10.1016/j.jsb.2012.09.006 10.1038/s41467-021-21251-y 10.1126/science.abi4506 10.1038/nature17200 10.1016/bs.aivir.2018.01.001 10.1073/pnas.1707304114 10.7150/ijbs.45472 10.1016/j.celrep.2022.111299 10.1056/NEJMp2118468 10.1038/s41401-020-0485-4 10.1038/s41590-018-0305-x 10.1038/s41586-021-03365-x 10.3389/fimmu.2020.576622 10.1038/nmicrobiol.2016.226 10.1038/s41586-020-2622-0 10.1016/j.jsb.2005.07.007 10.1038/s41579-018-0118-9 10.1038/s41467-019-12080-1 10.1016/j.cell.2021.03.028 10.7554/eLife.57659 10.1016/S1473-3099(20)30120-1 10.1038/s41467-021-23074-3 10.1006/jsbi.1996.0030 10.1016/j.celrep.2019.08.052 10.3389/fimmu.2021.701501 10.1016/j.celrep.2020.107725 10.1371/journal.ppat.1008665 10.1016/j.bbrc.2004.09.106 10.1016/j.virol.2017.12.006 10.1016/j.cell.2021.09.015 10.1016/j.jsb.2006.05.009 10.1016/B978-0-12-801238-3.11634-4 10.1038/s41591-021-01377-8 |
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| References | Martinez (CR8) 2021; 373 Pallesen (CR15) 2017; 114 Mastronarde (CR31) 2005; 152 Ueda (CR18) 2020; 9 Antanasijevic (CR27) 2020; 16 McCallum (CR28) 2021; 184 Walls (CR29) 2022; 40 Huang, Yang, Xu, Xu, Liu (CR12) 2020; 41 CR30 Frank (CR24) 1996; 116 Tang (CR32) 2007; 157 Duan (CR11) 2020; 11 Ye (CR1) 2020; 16 Cohen (CR9) 2021; 371 Dong, Du, Gardner (CR4) 2020; 20 Martínez-Flores (CR16) 2021; 12 Kirchdoerfer (CR17) 2016; 531 CR3 Wang (CR20) 2019; 28 Scheres (CR33) 2012; 180 Song (CR7) 2021; 12 He (CR13) 2004; 324 Hsieh (CR19) 2021; 37 Lv (CR25) 2020; 31 Corman, Muth, Niemeyer, Drosten (CR2) 2018; 100 Walls (CR10) 2021; 184 Wargacki (CR23) 2021; 12 Corbett (CR35) 2020; 586 Morens, Taubenberger, Fauci (CR6) 2021; 386 Kanekiyo (CR14) 2019; 20 Brouwer (CR26) 2019; 10 Cui, Li, Shi (CR5) 2019; 17 Cockrell (CR21) 2016; 2 Boyoglu-Barnum (CR22) 2021; 592 Douglas, Kocher, Scobey, Baric, Cockrell (CR34) 2018; 517 AC Walls (41661_CR29) 2022; 40 KS Corbett (41661_CR35) 2020; 586 ZW Ye (41661_CR1) 2020; 16 Y Huang (41661_CR12) 2020; 41 J Cui (41661_CR5) 2019; 17 L Duan (41661_CR11) 2020; 11 J Pallesen (41661_CR15) 2017; 114 VM Corman (41661_CR2) 2018; 100 S Boyoglu-Barnum (41661_CR22) 2021; 592 DM Morens (41661_CR6) 2021; 386 AJ Wargacki (41661_CR23) 2021; 12 A Antanasijevic (41661_CR27) 2020; 16 41661_CR30 G Song (41661_CR7) 2021; 12 H Lv (41661_CR25) 2020; 31 SH Scheres (41661_CR33) 2012; 180 E Dong (41661_CR4) 2020; 20 DN Mastronarde (41661_CR31) 2005; 152 AA Cohen (41661_CR9) 2021; 371 AC Walls (41661_CR10) 2021; 184 M McCallum (41661_CR28) 2021; 184 G Tang (41661_CR32) 2007; 157 41661_CR3 CL Hsieh (41661_CR19) 2021; 37 N Wang (41661_CR20) 2019; 28 MG Douglas (41661_CR34) 2018; 517 D Martínez-Flores (41661_CR16) 2021; 12 PJM Brouwer (41661_CR26) 2019; 10 RN Kirchdoerfer (41661_CR17) 2016; 531 AS Cockrell (41661_CR21) 2016; 2 DR Martinez (41661_CR8) 2021; 373 M Kanekiyo (41661_CR14) 2019; 20 G Ueda (41661_CR18) 2020; 9 Y He (41661_CR13) 2004; 324 J Frank (41661_CR24) 1996; 116 36380759 - Res Sq. 2022 Nov 07:rs.3.rs-2199814. doi: 10.21203/rs.3.rs-2199814/v1. |
| References_xml | – volume: 371 start-page: 735 year: 2021 end-page: 741 ident: CR9 article-title: Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice publication-title: Science doi: 10.1126/science.abf6840 – volume: 37 start-page: 109929 year: 2021 ident: CR19 article-title: Stabilized coronavirus spike stem elicits a broadly protective antibody publication-title: Cell Rep. doi: 10.1016/j.celrep.2021.109929 – volume: 180 start-page: 519 year: 2012 end-page: 530 ident: CR33 article-title: RELION: implementation of a Bayesian approach to cryo-EM structure determination publication-title: J. Struct. Biol. doi: 10.1016/j.jsb.2012.09.006 – volume: 12 year: 2021 ident: CR23 article-title: Complete and cooperative in vitro assembly of computationally designed self-assembling protein nanomaterials publication-title: Nat. Commun. doi: 10.1038/s41467-021-21251-y – volume: 373 start-page: 991 year: 2021 end-page: 998 ident: CR8 article-title: Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice publication-title: Science doi: 10.1126/science.abi4506 – volume: 531 start-page: 118 year: 2016 end-page: 121 ident: CR17 article-title: Pre-fusion structure of a human coronavirus spike protein publication-title: Nature doi: 10.1038/nature17200 – volume: 100 start-page: 163 year: 2018 end-page: 188 ident: CR2 article-title: Hosts and sources of endemic human coronaviruses publication-title: Adv. Virus Res. doi: 10.1016/bs.aivir.2018.01.001 – volume: 114 start-page: E7348 year: 2017 end-page: E7357 ident: CR15 article-title: Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1707304114 – ident: CR30 – volume: 16 start-page: 1686 year: 2020 end-page: 1697 ident: CR1 article-title: Zoonotic origins of human coronaviruses publication-title: Int. J. Biol. Sci. doi: 10.7150/ijbs.45472 – volume: 40 start-page: 111299 year: 2022 ident: CR29 article-title: Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice publication-title: Cell Rep. doi: 10.1016/j.celrep.2022.111299 – volume: 386 start-page: 297 year: 2021 end-page: 299 ident: CR6 article-title: Universal coronavirus vaccines—an urgent need publication-title: N. Engl. J. Med. doi: 10.1056/NEJMp2118468 – volume: 41 start-page: 1141 year: 2020 end-page: 1149 ident: CR12 article-title: Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 publication-title: Acta Pharmacol. Sin. doi: 10.1038/s41401-020-0485-4 – volume: 20 start-page: 362 year: 2019 end-page: 372 ident: CR14 article-title: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses publication-title: Nat. Immunol. doi: 10.1038/s41590-018-0305-x – volume: 592 start-page: 623 year: 2021 end-page: 628 ident: CR22 article-title: Quadrivalent influenza nanoparticle vaccines induce broad protection publication-title: Nature doi: 10.1038/s41586-021-03365-x – volume: 11 start-page: 576622 year: 2020 ident: CR11 article-title: The SARS-CoV-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: implications for the design of spike-based vaccine immunogens publication-title: Front. Immunol. doi: 10.3389/fimmu.2020.576622 – volume: 2 start-page: 16226 year: 2016 ident: CR21 article-title: A mouse model for MERS coronavirus-induced acute respiratory distress syndrome publication-title: Nat. Microbiol. doi: 10.1038/nmicrobiol.2016.226 – volume: 586 start-page: 567 year: 2020 end-page: 571 ident: CR35 article-title: SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness publication-title: Nature doi: 10.1038/s41586-020-2622-0 – volume: 152 start-page: 36 year: 2005 end-page: 51 ident: CR31 article-title: Automated electron microscope tomography using robust prediction of specimen movements publication-title: J. Struct. Biol. doi: 10.1016/j.jsb.2005.07.007 – volume: 17 start-page: 181 year: 2019 end-page: 192 ident: CR5 article-title: Origin and evolution of pathogenic coronaviruses publication-title: Nat. Rev. Microbiol. doi: 10.1038/s41579-018-0118-9 – volume: 10 year: 2019 ident: CR26 article-title: Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle publication-title: Nat. Commun. doi: 10.1038/s41467-019-12080-1 – volume: 184 start-page: 2332 year: 2021 end-page: 2347.e2316 ident: CR28 article-title: N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2 publication-title: Cell doi: 10.1016/j.cell.2021.03.028 – volume: 9 start-page: e57659 year: 2020 ident: CR18 article-title: Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens publication-title: Elife doi: 10.7554/eLife.57659 – volume: 20 start-page: 533 year: 2020 end-page: 534 ident: CR4 article-title: An interactive web-based dashboard to track COVID-19 in real time publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(20)30120-1 – ident: CR3 – volume: 12 year: 2021 ident: CR7 article-title: Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection publication-title: Nat. Commun. doi: 10.1038/s41467-021-23074-3 – volume: 116 start-page: 190 year: 1996 end-page: 199 ident: CR24 article-title: SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields publication-title: J. Struct. Biol. doi: 10.1006/jsbi.1996.0030 – volume: 28 start-page: 3395 year: 2019 end-page: 3405.e3396 ident: CR20 article-title: Structural definition of a neutralization-sensitive epitope on the MERS-CoV S1-NTD publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.08.052 – volume: 12 start-page: 701501 year: 2021 ident: CR16 article-title: SARS-CoV-2 vaccines based on the spike glycoprotein and implications of new viral variants publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.701501 – volume: 31 start-page: 107725 year: 2020 ident: CR25 article-title: Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections publication-title: Cell Rep. doi: 10.1016/j.celrep.2020.107725 – volume: 16 start-page: e1008665 year: 2020 ident: CR27 article-title: Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1008665 – volume: 324 start-page: 773 year: 2004 end-page: 781 ident: CR13 article-title: Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2004.09.106 – volume: 517 start-page: 98 year: 2018 end-page: 107 ident: CR34 article-title: Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease publication-title: Virology doi: 10.1016/j.virol.2017.12.006 – volume: 184 start-page: 5432 year: 2021 end-page: 5447.e5416 ident: CR10 article-title: Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines publication-title: Cell doi: 10.1016/j.cell.2021.09.015 – volume: 157 start-page: 38 year: 2007 end-page: 46 ident: CR32 article-title: EMAN2: an extensible image processing suite for electron microscopy publication-title: J. Struct. Biol. doi: 10.1016/j.jsb.2006.05.009 – volume: 184 start-page: 2332 year: 2021 ident: 41661_CR28 publication-title: Cell doi: 10.1016/j.cell.2021.03.028 – volume: 100 start-page: 163 year: 2018 ident: 41661_CR2 publication-title: Adv. Virus Res. doi: 10.1016/bs.aivir.2018.01.001 – volume: 184 start-page: 5432 year: 2021 ident: 41661_CR10 publication-title: Cell doi: 10.1016/j.cell.2021.09.015 – volume: 180 start-page: 519 year: 2012 ident: 41661_CR33 publication-title: J. Struct. Biol. doi: 10.1016/j.jsb.2012.09.006 – volume: 20 start-page: 533 year: 2020 ident: 41661_CR4 publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(20)30120-1 – volume: 586 start-page: 567 year: 2020 ident: 41661_CR35 publication-title: Nature doi: 10.1038/s41586-020-2622-0 – volume: 531 start-page: 118 year: 2016 ident: 41661_CR17 publication-title: Nature doi: 10.1038/nature17200 – volume: 386 start-page: 297 year: 2021 ident: 41661_CR6 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMp2118468 – ident: 41661_CR3 doi: 10.1016/B978-0-12-801238-3.11634-4 – volume: 157 start-page: 38 year: 2007 ident: 41661_CR32 publication-title: J. Struct. Biol. doi: 10.1016/j.jsb.2006.05.009 – volume: 114 start-page: E7348 year: 2017 ident: 41661_CR15 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1707304114 – volume: 373 start-page: 991 year: 2021 ident: 41661_CR8 publication-title: Science doi: 10.1126/science.abi4506 – volume: 371 start-page: 735 year: 2021 ident: 41661_CR9 publication-title: Science doi: 10.1126/science.abf6840 – volume: 20 start-page: 362 year: 2019 ident: 41661_CR14 publication-title: Nat. Immunol. doi: 10.1038/s41590-018-0305-x – volume: 12 year: 2021 ident: 41661_CR23 publication-title: Nat. Commun. doi: 10.1038/s41467-021-21251-y – volume: 16 start-page: 1686 year: 2020 ident: 41661_CR1 publication-title: Int. J. Biol. Sci. doi: 10.7150/ijbs.45472 – volume: 17 start-page: 181 year: 2019 ident: 41661_CR5 publication-title: Nat. Rev. Microbiol. doi: 10.1038/s41579-018-0118-9 – volume: 11 start-page: 576622 year: 2020 ident: 41661_CR11 publication-title: Front. Immunol. doi: 10.3389/fimmu.2020.576622 – volume: 16 start-page: e1008665 year: 2020 ident: 41661_CR27 publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1008665 – volume: 2 start-page: 16226 year: 2016 ident: 41661_CR21 publication-title: Nat. Microbiol. doi: 10.1038/nmicrobiol.2016.226 – volume: 37 start-page: 109929 year: 2021 ident: 41661_CR19 publication-title: Cell Rep. doi: 10.1016/j.celrep.2021.109929 – volume: 28 start-page: 3395 year: 2019 ident: 41661_CR20 publication-title: Cell Rep. doi: 10.1016/j.celrep.2019.08.052 – volume: 12 year: 2021 ident: 41661_CR7 publication-title: Nat. Commun. doi: 10.1038/s41467-021-23074-3 – volume: 324 start-page: 773 year: 2004 ident: 41661_CR13 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2004.09.106 – volume: 116 start-page: 190 year: 1996 ident: 41661_CR24 publication-title: J. Struct. Biol. doi: 10.1006/jsbi.1996.0030 – volume: 9 start-page: e57659 year: 2020 ident: 41661_CR18 publication-title: Elife doi: 10.7554/eLife.57659 – volume: 40 start-page: 111299 year: 2022 ident: 41661_CR29 publication-title: Cell Rep. doi: 10.1016/j.celrep.2022.111299 – volume: 41 start-page: 1141 year: 2020 ident: 41661_CR12 publication-title: Acta Pharmacol. Sin. doi: 10.1038/s41401-020-0485-4 – volume: 12 start-page: 701501 year: 2021 ident: 41661_CR16 publication-title: Front. Immunol. doi: 10.3389/fimmu.2021.701501 – volume: 152 start-page: 36 year: 2005 ident: 41661_CR31 publication-title: J. Struct. Biol. doi: 10.1016/j.jsb.2005.07.007 – ident: 41661_CR30 doi: 10.1038/s41591-021-01377-8 – volume: 10 year: 2019 ident: 41661_CR26 publication-title: Nat. Commun. doi: 10.1038/s41467-019-12080-1 – volume: 517 start-page: 98 year: 2018 ident: 41661_CR34 publication-title: Virology doi: 10.1016/j.virol.2017.12.006 – volume: 592 start-page: 623 year: 2021 ident: 41661_CR22 publication-title: Nature doi: 10.1038/s41586-021-03365-x – volume: 31 start-page: 107725 year: 2020 ident: 41661_CR25 publication-title: Cell Rep. doi: 10.1016/j.celrep.2020.107725 – reference: 36380759 - Res Sq. 2022 Nov 07:rs.3.rs-2199814. doi: 10.21203/rs.3.rs-2199814/v1. |
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| Snippet | Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates demonstrate... Abstract Multivalent antigen display is a fast-growing area of interest toward broadly protective vaccines. Current nanoparticle-based vaccine candidates... |
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| Title | Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera |
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