Mechanism of Cone Degeneration in Retinitis Pigmentosa

• Published in: Cellular and molecular neurobiology Vol. 43; no. 3; pp. 1037 - 1048
• Main Authors: Song, De-Juan, Bao, Xiao-Li, Fan, Bin, Li, Guang-Yu
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2023; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Blindness; Blindness - metabolism; Cell Biology; Cones; Degeneration; Genetic disorders; Humans; Neurobiology; Neurosciences; Nyctalopia; Oxidative Stress; Photoreceptors; Retinal Cone Photoreceptor Cells - metabolism; Retinal Rod Photoreceptor Cells - metabolism; Retinitis; Retinitis pigmentosa; Retinitis Pigmentosa - genetics; Retinitis Pigmentosa - metabolism; Retinitis Pigmentosa - therapy; Review Paper; Trophic factors; Oxidative stress; Retinal cone photoreceptor cells; Inflammation; RdCVF; Retinitis pigmentosa; Trophic factors

Retinitis pigmentosa (RP) is a group of genetic disorders resulting in inherited blindness due to the degeneration of rod and cone photoreceptors. The various mechanisms underlying rod degeneration primarily rely on genetic mutations, leading to night blindness initially. Cones gradually degenerate...