MicroRNA-125b-5p mimic inhibits acute liver failure

• Published in: Nature communications Vol. 7; no. 1; pp. 11916 - 11
• Main Authors: Yang, Dakai, Yuan, Qinggong, Balakrishnan, Asha, Bantel, Heike, Klusmann, Jan-Henning, Manns, Michael P, Ott, Michael, Cantz, Tobias, Sharma, Amar Deep
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 23.06.2016; Nature Portfolio
• Subjects: Analgesics; Apoptosis; Biomarkers; Cell death; Drug dosages; Drug overdose; Hepatitis; Hepatology; Liver; Medical schools; MicroRNAs; Mortality; Toxicity; Germany

The lack of broad-spectrum anti-acute liver failure (ALF) therapeutic agents contributes to ALF-related mortality. MicroRNAs (miRNAs) are suggested to be potent serum biomarkers for ALF, but their functional and therapeutic relevance in ALF are unclear. Here we show an unbiased approach, using two c...