An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord injury

• Published in: Bioactive materials Vol. 6; no. 11; pp. 3766 - 3781
• Main Authors: Li, Ge, Zhang, Bao, Sun, Jia-hui, Shi, Li-yang, Huang, Meng-yao, Huang, Li-jun, Lin, Zi-jing, Lin, Qiong-yu, Lai, Bi-qin, Ma, Yuan-huan, Jiang, Bin, Ding, Ying, Zhang, Hong-bo, Li, Miao-xin, Zhu, Ping, Wang, Ya-qiong, Zeng, Xiang, Zeng, Yuan-shan
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.11.2021; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Neural network tissue; Neurotrophin-3; Self-organization; Spinal cord injury; Tropomyosin kinase receptor C; Tropomyosin kinase receptor C; Neural network tissue; Neurotrophin-3; Spinal cord injury; Self-organization

The mechanism underlying neurogenesis during embryonic spinal cord development involves a specific ligand/receptor interaction, which may be help guide neuroengineering to boost stem cell-based neural regeneration for the structural and functional repair of spinal cord injury. Herein, we hypothesize...