Isotopologues of potassium 2,2,2-trifluoroethoxide for applications in positron emission tomography and beyond

• Published in: Nature communications Vol. 15; no. 1; pp. 5798 - 10
• Main Authors: Zhao, Qunchao, Telu, Sanjay, Jana, Susovan, Morse, Cheryl L., Pike, Victor W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 140/131; 140/58; 639/638/403/933; 639/638/549/933; 692/4017; Aliphatic compounds; Carbon Radioisotopes - chemistry; Drug development; Drug discovery; Drugs; Fluorine; Fluorine Radioisotopes - chemistry; Formaldehyde; Humanities and Social Sciences; Humans; Isotopic labeling; Medical imaging; multidisciplinary; Polymers; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Potassium; Potassium - chemistry; Radioactive tracers; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - chemistry; Science; Science (multidisciplinary); Stable isotopes; Substrates; Tomography; Tracers; Transition metals; Trifluoromethane

The 2,2,2-trifluoroethoxy group increasingly features in drugs and potential tracers for biomedical imaging with positron emission tomography (PET). Herein, we describe a rapid and transition metal-free conversion of fluoroform with paraformaldehyde into highly reactive potassium 2,2,2-trifluoroetho...