A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease

• Published in: Nature communications Vol. 14; no. 1; pp. 7030 - 22
• Main Authors: Aron, Liviu, Qiu, Chenxi, Ngian, Zhen Kai, Liang, Marianna, Drake, Derek, Choi, Jaejoon, Fernandez, Marty A., Roche, Perle, Bunting, Emma L., Lacey, Ella K., Hamplova, Sara E., Yuan, Monlan, Wolfe, Michael S., Bennett, David A., Lee, Eunjung A., Yankner, Bruce A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.11.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/2; 42/44; 45/15; 45/41; 631/378/1689/1283; 631/378/2611; 64/60; Accumulation; Aging; Aging (artificial); Aging - metabolism; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - prevention & control; Alzheimer's disease; Amyloid; Amyloid beta-Peptides - metabolism; Animal models; Animals; Apoptosis; Cognitive ability; Cognitive Dysfunction - genetics; Cognitive Dysfunction - prevention & control; Deposition; Disease Models, Animal; Humanities and Social Sciences; Humans; Kinases; Mice; Mice, Transgenic; multidisciplinary; Neurodegeneration; Neurodegenerative diseases; Pathology; Protein folding; Proteins; Science; Science (multidisciplinary); Secretase; Tau protein; tau Proteins - metabolism; β-Amyloid; β-Catenin

Many aging individuals accumulate the pathology of Alzheimer’s disease (AD) without evidence of cognitive decline. Here we describe an integrated neurodegeneration checkpoint response to early pathological changes that restricts further disease progression and preserves cognitive function. Checkpoin...