Phosphorylation of INF2 by AMPK promotes mitochondrial fission and oncogenic function in endometrial cancer

• Published in: Cell death & disease Vol. 15; no. 1; pp. 65 - 11
• Main Authors: Ding, Yan, Lv, Zeheng, Cao, Wenxin, Shi, Wenming, He, Qizhi, Gao, Kun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.01.2024; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/31; 13/89; 14/19; 38/1; 38/70; 42/109; 631/67/1517/1931; 631/80/642/333; 82/29; 82/81; Actin; AMP-activated protein kinase; AMP-Activated Protein Kinases - metabolism; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell growth; Dynamin; Dynamins - metabolism; Endometrial cancer; Endometrial Neoplasms - genetics; Endometrial Neoplasms - metabolism; Endometrium; Endoplasmic reticulum; Female; Formins - metabolism; Humans; Immunology; Kinases; Life Sciences; Localization; Metastases; Mitochondria; Mitochondria - metabolism; Mitochondrial Dynamics; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Molecular modelling; Organelles; Phosphorylation; Uterine cancer
• ISSN: 2041-4889; 2041-4889
• DOI: 10.1038/s41419-024-06431-0

Mitochondria are highly dynamic organelles capable of altering their sizes and shapes to maintain metabolic balance through coordinated fission and fusion processes. In various cancer types, mitochondrial hyperfragmentation has been frequently observed, contributing to the progression of cancer towa...