The predictive value of soluble urokinase plasminogen activator receptor (SuPAR) regarding 90-day mortality and 12-month neurological outcome in critically ill patients after out-of-hospital cardiac arrest. Data from the prospective FINNRESUSCI study

• Published in: Resuscitation Vol. 85; no. 11; pp. 1562 - 1567
• Main Authors: Jalkanen, Ville, Vaahersalo, Jukka, Pettilä, Ville, Kurola, Jouni, Varpula, Tero, Tiainen, Marjaana, Huhtala, Heini, Alaspää, Ari, Hovilehto, Seppo, Kiviniemi, Outi, Kuitunen, Anne, Tenhunen, Jyrki
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.11.2014
• Subjects: Aged; Biomarkers; Biomarkers - blood; Cardiopulmonary Resuscitation - adverse effects; Cardiopulmonary Resuscitation - methods; Cardiopulmonary Resuscitation - mortality; Critical Illness - mortality; Critical Illness - therapy; Databases, Factual; Emergency; Female; Hospital Mortality - trends; Humans; Hypothermia, Induced - adverse effects; Hypothermia, Induced - methods; Intensive Care Units; Kaplan-Meier Estimate; Male; Middle Aged; Nervous System Diseases - epidemiology; Nervous System Diseases - etiology; Nervous System Diseases - physiopathology; OHCA; Out-of-hospital cardiac arrest; Out-of-Hospital Cardiac Arrest - mortality; Out-of-Hospital Cardiac Arrest - therapy; Predictive Value of Tests; Prognosis; Prognostication after cardiac arrest; Prospective Studies; Receptors, Urokinase Plasminogen Activator - blood; Reperfusion Injury - blood; Reperfusion Injury - etiology; Reperfusion Injury - physiopathology; Resuscitation; Risk Assessment; ROC Curve; Severity of Illness Index; Solubility; Soluble urokinase plasminogen activator receptor (suPAR); Survival Analysis; Systemic Inflammatory Response Syndrome - blood; Systemic Inflammatory Response Syndrome - etiology; Systemic Inflammatory Response Syndrome - physiopathology; Time Factors; Treatment Outcome; Biomarkers; Out-of-hospital cardiac arrest; Soluble urokinase plasminogen activator receptor (suPAR); OHCA; Resuscitation; Prognostication after cardiac arrest

Abstract Aim The whole body ischaemia–reperfusion after cardiac arrest (CA) induces a systemic inflammation-reperfusion response. The expression of urokinase plasminogen activator receptor (uPAR) is known to be induced after hypoxia and increased levels of soluble form suPAR have been measured after...