LC-MS Profiling of Kakkonto and Identification of Ephedrine as a Key Component for Its Anti-Glycation Activity

• Published in: Molecules Vol. 28; no. 11; p. 4409
• Main Authors: Ito, Kaori, Kikuchi, Takashi, Ikube, Kanako, Otsuki, Kouharu, Koike, Kazuo, Li, Wei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.05.2023; MDPI
• Subjects: advanced glycation end products; Alzheimer's disease; anti-glycation activity; Antifungal agents; Chromatography, Liquid; Diabetes; Drugs, Chinese Herbal; Ephedrine; Glucose; Glycation End Products, Advanced; Kakkonto; Kampo; Kampo; Kakkonto; anti-glycation activity; advanced glycation end products; ephedrine; Magnesium Oxide; Organic chemistry; Prescriptions; Proteins; Pyruvaldehyde; QD241-441; Tandem Mass Spectrometry; Japan; Kampo; ephedrine; Kakkonto; advanced glycation end products; anti-glycation activity

A total of 147 oral Kampo prescriptions, which are used clinically in Japan, were evaluated for their anti-glycation activity. Kakkonto demonstrated significant anti-glycation activity, prompting further analysis of its chemical constituents using LC-MS, which revealed the presence of two alkaloids,...