Predisposition to Behçet’s disease and VKH syndrome by genetic variants of miR-182
Previous studies have identified miR-182 , miR-27a , FoxO1 , and IL2RA as regulatory factors for Treg cell development and function. In order to investigate the association of miR-182, miR-27a, FoxO1 , and IL2RA gene polymorphisms with Behçet’s disease (BD) and Vogt–Koyanagi–Harada (VKH) syndrome in...
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Published in | Journal of molecular medicine (Berlin, Germany) Vol. 92; no. 9; pp. 961 - 967 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.09.2014
Springer Nature B.V |
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Abstract | Previous studies have identified
miR-182
,
miR-27a
,
FoxO1
, and
IL2RA
as regulatory factors for Treg cell development and function. In order to investigate the association of miR-182, miR-27a,
FoxO1
, and
IL2RA
gene polymorphisms with Behçet’s disease (BD) and Vogt–Koyanagi–Harada (VKH) syndrome in a Chinese Han population, a two-stage association study was performed in 820 BD, 900 VKH patients, and 1,800 controls using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. In the first stage study, association analysis of 10 single nucleotide polymorphisms (SNPs) was performed in 400 BD, 400 VKH patients, and 600 controls. The results showed significantly decreased frequencies of the miR-182/rs76481776 CC genotype and C allele in BD (
P
= 3.36 × 10
−4
, OR = 0.55;
P
= 4.74 × 10
−4
, OR = 0.59) and VKH patients (
P
= 1.11 × 10
−4
, OR = 0.53;
P
= 1.26 × 10
−4
, OR = 0.56). No significant association of the other nine SNPs with BD or VKH was observed. In the second stage study, association analysis of miR-182/rs76481776 was performed in 420 BD, 500 VKH patients, and 1,200 controls. The second stage and combined studies confirmed the association of miR-182/rs76481776 with BD (CC genotype:
P
= 3.25 × 10
−7
, OR = 0.58; C allele:
P
= 1.81 × 10
−7
, OR = 0.60) and VKH (CC genotype:
P
= 7.89 × 10
−8
, OR = 0.57; C allele:
P
= 2.52 × 10
−8
, OR = 0.59). Real-time PCR analysis showed a significantly increased expression of miR-182 in TT/CT cases compared to CC cases in anti-CD3/CD28 antibodies-stimulated CD4
+
T cells (
P
= 2.1 × 10
−2
). In conclusion, this study suggests that miR-182, but not miR-27a,
FoxO1
, and
IL2RA
, contributes to the genetic susceptibility of BD and VKH.
Key Message
MiR-182 contributes to genetic susceptibility of BD and VKH.
No significant association of miR-27a, FoxO1, and IL2RA with BD or VKH was observed.
Significantly increased expression of miR-182 in TT/CT cases compared to CC cases was observed. |
---|---|
AbstractList | Previous studies have identified
miR-182
,
miR-27a
,
FoxO1
, and
IL2RA
as regulatory factors for Treg cell development and function. In order to investigate the association of miR-182, miR-27a,
FoxO1
, and
IL2RA
gene polymorphisms with Behçet’s disease (BD) and Vogt–Koyanagi–Harada (VKH) syndrome in a Chinese Han population, a two-stage association study was performed in 820 BD, 900 VKH patients, and 1,800 controls using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. In the first stage study, association analysis of 10 single nucleotide polymorphisms (SNPs) was performed in 400 BD, 400 VKH patients, and 600 controls. The results showed significantly decreased frequencies of the miR-182/rs76481776 CC genotype and C allele in BD (
P
= 3.36 × 10
−4
, OR = 0.55;
P
= 4.74 × 10
−4
, OR = 0.59) and VKH patients (
P
= 1.11 × 10
−4
, OR = 0.53;
P
= 1.26 × 10
−4
, OR = 0.56). No significant association of the other nine SNPs with BD or VKH was observed. In the second stage study, association analysis of miR-182/rs76481776 was performed in 420 BD, 500 VKH patients, and 1,200 controls. The second stage and combined studies confirmed the association of miR-182/rs76481776 with BD (CC genotype:
P
= 3.25 × 10
−7
, OR = 0.58; C allele:
P
= 1.81 × 10
−7
, OR = 0.60) and VKH (CC genotype:
P
= 7.89 × 10
−8
, OR = 0.57; C allele:
P
= 2.52 × 10
−8
, OR = 0.59). Real-time PCR analysis showed a significantly increased expression of miR-182 in TT/CT cases compared to CC cases in anti-CD3/CD28 antibodies-stimulated CD4
+
T cells (
P
= 2.1 × 10
−2
). In conclusion, this study suggests that miR-182, but not miR-27a,
FoxO1
, and
IL2RA
, contributes to the genetic susceptibility of BD and VKH.
Key Message
MiR-182 contributes to genetic susceptibility of BD and VKH.
No significant association of miR-27a, FoxO1, and IL2RA with BD or VKH was observed.
Significantly increased expression of miR-182 in TT/CT cases compared to CC cases was observed. Previous studies have identified miR-182, miR-27a, FoxO1, and IL2RA as regulatory factors for Treg cell development and function. In order to investigate the association of miR-182, miR-27a, FoxO1, and IL2RA gene polymorphisms with Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population, a two-stage association study was performed in 820 BD, 900 VKH patients, and 1,800 controls using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. In the first stage study, association analysis of 10 single nucleotide polymorphisms (SNPs) was performed in 400 BD, 400 VKH patients, and 600 controls. The results showed significantly decreased frequencies of the miR-182/rs76481776 CC genotype and C allele in BD (P=3.3610 super(-4), OR=0.55; P=4.7410 super(-4), OR=0.59) and VKH patients (P=1.1110 super(-4), OR=0.53; P=1.2610 super(-4), OR=0.56). No significant association of the other nine SNPs with BD or VKH was observed. In the second stage study, association analysis of miR-182/rs76481776 was performed in 420 BD, 500 VKH patients, and 1,200 controls. The second stage and combined studies confirmed the association of miR-182/rs76481776 with BD (CC genotype: P=3.2510 super(-7), OR=0.58; C allele: P=1.8110 super(-7), OR=0.60) and VKH (CC genotype: P=7.8910 super(-8), OR=0.57; C allele: P=2.5210 super(-8), OR=0.59). Real-time PCR analysis showed a significantly increased expression of miR-182 in TT/CT cases compared to CC cases in anti-CD3/CD28 antibodies-stimulated CD4 super(+) T cells (P=2.110 super(-2)). In conclusion, this study suggests that miR-182, but not miR-27a, FoxO1, and IL2RA, contributes to the genetic susceptibility of BD and VKH. Key Message: MiR-182 contributes to genetic susceptibility of BD and VKH.No significant association of miR-27a, FoxO1, and IL2RA with BD or VKH was observed.Significantly increased expression of miR-182 in TT/CT cases compared to CC cases was observed. UNLABELLEDPrevious studies have identified miR-182, miR-27a, FoxO1, and IL2RA as regulatory factors for Treg cell development and function. In order to investigate the association of miR-182, miR-27a, FoxO1, and IL2RA gene polymorphisms with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population, a two-stage association study was performed in 820 BD, 900 VKH patients, and 1,800 controls using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. In the first stage study, association analysis of 10 single nucleotide polymorphisms (SNPs) was performed in 400 BD, 400 VKH patients, and 600 controls. The results showed significantly decreased frequencies of the miR-182/rs76481776 CC genotype and C allele in BD (P = 3.36 × 10(-4), OR = 0.55; P = 4.74 × 10(-4), OR = 0.59) and VKH patients (P = 1.11 × 10(-4), OR = 0.53; P = 1.26 × 10(-4), OR = 0.56). No significant association of the other nine SNPs with BD or VKH was observed. In the second stage study, association analysis of miR-182/rs76481776 was performed in 420 BD, 500 VKH patients, and 1,200 controls. The second stage and combined studies confirmed the association of miR-182/rs76481776 with BD (CC genotype: P = 3.25 × 10(-7), OR = 0.58; C allele: P = 1.81 × 10(-7), OR = 0.60) and VKH (CC genotype: P = 7.89 × 10(-8), OR = 0.57; C allele: P = 2.52 × 10(-8), OR = 0.59). Real-time PCR analysis showed a significantly increased expression of miR-182 in TT/CT cases compared to CC cases in anti-CD3/CD28 antibodies-stimulated CD4(+) T cells (P = 2.1 × 10(-2)). In conclusion, this study suggests that miR-182, but not miR-27a, FoxO1, and IL2RA, contributes to the genetic susceptibility of BD and VKH. KEY MESSAGEMiR-182 contributes to genetic susceptibility of BD and VKH. No significant association of miR-27a, FoxO1, and IL2RA with BD or VKH was observed. Significantly increased expression of miR-182 in TT/CT cases compared to CC cases was observed. Previous studies have identified miR-182, miR-27a, FoxO1, and IL2RA as regulatory factors for Treg cell development and function. In order to investigate the association of miR-182, miR-27a, FoxO1, and IL2RA gene polymorphisms with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population, a two-stage association study was performed in 820 BD, 900 VKH patients, and 1,800 controls using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. In the first stage study, association analysis of 10 single nucleotide polymorphisms (SNPs) was performed in 400 BD, 400 VKH patients, and 600 controls. The results showed significantly decreased frequencies of the miR-182/rs76481776 CC genotype and C allele in BD (P=3.36×10^sup -4^, OR=0.55; P=4.74×10^sup -4^, OR=0.59) and VKH patients (P=1.11×10^sup -4^, OR=0.53; P=1.26×10^sup -4^, OR=0.56). No significant association of the other nine SNPs with BD or VKH was observed. In the second stage study, association analysis of miR-182/rs76481776 was performed in 420 BD, 500 VKH patients, and 1,200 controls. The second stage and combined studies confirmed the association of miR-182/rs76481776 with BD (CC genotype: P=3.25×10^sup -7^, OR=0.58; C allele: P=1.81×10^sup -7^, OR=0.60) and VKH (CC genotype: P=7.89×10^sup -8^, OR=0.57; C allele: P=2.52×10^sup -8^, OR=0.59). Real-time PCR analysis showed a significantly increased expression of miR-182 in TT/CT cases compared to CC cases in anti-CD3/CD28 antibodies-stimulated CD4^sup +^ T cells (P=2.1×10^sup -2^). In conclusion, this study suggests that miR-182, but not miR-27a, FoxO1, and IL2RA, contributes to the genetic susceptibility of BD and VKH. MiR-182 contributes to genetic susceptibility of BD and VKH. No significant association of miR-27a, FoxO1, and IL2RA with BD or VKH was observed. Significantly increased expression of miR-182 in TT/CT cases compared to CC cases was observed. [PUBLICATION ABSTRACT] Previous studies have identified miR-182, miR-27a, FoxO1, and IL2RA as regulatory factors for Treg cell development and function. In order to investigate the association of miR-182, miR-27a, FoxO1, and IL2RA gene polymorphisms with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population, a two-stage association study was performed in 820 BD, 900 VKH patients, and 1,800 controls using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. In the first stage study, association analysis of 10 single nucleotide polymorphisms (SNPs) was performed in 400 BD, 400 VKH patients, and 600 controls. The results showed significantly decreased frequencies of the miR-182/rs76481776 CC genotype and C allele in BD (P = 3.36 × 10(-4), OR = 0.55; P = 4.74 × 10(-4), OR = 0.59) and VKH patients (P = 1.11 × 10(-4), OR = 0.53; P = 1.26 × 10(-4), OR = 0.56). No significant association of the other nine SNPs with BD or VKH was observed. In the second stage study, association analysis of miR-182/rs76481776 was performed in 420 BD, 500 VKH patients, and 1,200 controls. The second stage and combined studies confirmed the association of miR-182/rs76481776 with BD (CC genotype: P = 3.25 × 10(-7), OR = 0.58; C allele: P = 1.81 × 10(-7), OR = 0.60) and VKH (CC genotype: P = 7.89 × 10(-8), OR = 0.57; C allele: P = 2.52 × 10(-8), OR = 0.59). Real-time PCR analysis showed a significantly increased expression of miR-182 in TT/CT cases compared to CC cases in anti-CD3/CD28 antibodies-stimulated CD4(+) T cells (P = 2.1 × 10(-2)). In conclusion, this study suggests that miR-182, but not miR-27a, FoxO1, and IL2RA, contributes to the genetic susceptibility of BD and VKH. MiR-182 contributes to genetic susceptibility of BD and VKH. No significant association of miR-27a, FoxO1, and IL2RA with BD or VKH was observed. Significantly increased expression of miR-182 in TT/CT cases compared to CC cases was observed. |
Author | Yang, Peizeng Yu, Hongsong Bai, Lin Kijlstra, Aize Liu, Yunjia |
Author_xml | – sequence: 1 givenname: Hongsong surname: Yu fullname: Yu, Hongsong organization: The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute – sequence: 2 givenname: Yunjia surname: Liu fullname: Liu, Yunjia organization: The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute – sequence: 3 givenname: Lin surname: Bai fullname: Bai, Lin organization: The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute – sequence: 4 givenname: Aize surname: Kijlstra fullname: Kijlstra, Aize organization: University Eye Clinic Maastricht – sequence: 5 givenname: Peizeng surname: Yang fullname: Yang, Peizeng email: peizengycmu@126.com organization: The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24801147$$D View this record in MEDLINE/PubMed |
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Keywords | miR-182 miR-27a Behçet’s disease Vogt–Koyanagi–Harada syndrome IL2RA FoxO1 |
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PublicationDate | 2014-09-01 |
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PublicationPlace | Berlin/Heidelberg |
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PublicationTitle | Journal of molecular medicine (Berlin, Germany) |
PublicationTitleAbbrev | J Mol Med |
PublicationTitleAlternate | J Mol Med (Berl) |
PublicationYear | 2014 |
Publisher | Springer Berlin Heidelberg Springer Nature B.V |
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Snippet | Previous studies have identified
miR-182
,
miR-27a
,
FoxO1
, and
IL2RA
as regulatory factors for Treg cell development and function. In order to investigate... Previous studies have identified miR-182, miR-27a, FoxO1, and IL2RA as regulatory factors for Treg cell development and function. In order to investigate the... UNLABELLEDPrevious studies have identified miR-182, miR-27a, FoxO1, and IL2RA as regulatory factors for Treg cell development and function. In order to... |
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SubjectTerms | Behcet Syndrome - genetics Biomedical and Life Sciences Biomedicine Gene Frequency Genetic Predisposition to Disease Genetic Variation Genotype Human Genetics Humans Internal Medicine MicroRNAs - genetics Molecular Medicine Original Article Polymorphism, Single Nucleotide Uveomeningoencephalitic Syndrome - genetics |
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Title | Predisposition to Behçet’s disease and VKH syndrome by genetic variants of miR-182 |
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