Drug screening on digital microfluidics for cancer precision medicine

• Published in: Nature communications Vol. 15; no. 1; pp. 4363 - 16
• Main Authors: Zhai, Jiao, Liu, Yingying, Ji, Weiqing, Huang, Xinru, Wang, Ping, Li, Yunyi, Li, Haoran, Wong, Ada Hang-Heng, Zhou, Xiong, Chen, Ping, Wang, Lianhong, Yang, Ning, Chen, Chi, Chen, Haitian, Mak, Pui-In, Deng, Chu-Xia, Martins, Rui, Yang, Mengsu, Ho, Tsung-Yi, Yi, Shuhong, Yao, Hailong, Jia, Yanwei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.05.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 49/62; 639/166/985; 639/166/987; 692/4028/67/1059; Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cancer; Cancer therapies; Cell culture; Cell Line, Tumor; Customization; Diagnosis; Drug screening; Drug Screening Assays, Antitumor - methods; Drugs; Female; Humanities and Social Sciences; Humans; Lab-On-A-Chip Devices; Liver cancer; Liver Neoplasms - drug therapy; Liver Neoplasms - genetics; Measuring instruments; Medical diagnosis; Mice; Microfluidic Analytical Techniques - instrumentation; Microfluidic Analytical Techniques - methods; Microfluidics; Microfluidics - methods; multidisciplinary; Precision medicine; Precision Medicine - methods; Science; Science (multidisciplinary); Tumor cells; Tumor suppression; Tumors; Xenograft Model Antitumor Assays; Xenotransplantation

Drug screening based on in-vitro primary tumor cell culture has demonstrated potential in personalized cancer diagnosis. However, the limited number of tumor cells, especially from patients with early stage cancer, has hindered the widespread application of this technique. Hence, we developed a digi...