Visible light-mediated difluoroalkylation of electron-deficient alkenes

A method for the reductive difluoroalkylation of electron-deficient alkenes using 1,1-difluorinated iodides mediated by irradiation with blue light is described. The reaction involves radical addition of 1,1-difluorinated radicals at the double bond followed by hydrogen atom transfer from sodium cya...

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Published inBeilstein journal of organic chemistry Vol. 14; no. 1; pp. 1637 - 1641
Main Authors Supranovich, Vyacheslav I, Levin, Vitalij V, Struchkova, Marina I, Hu, Jinbo, Dilman, Alexander D
Format Journal Article
LanguageEnglish
Published Germany Beilstein-Institut zur Föerderung der Chemischen Wissenschaften 02.07.2018
Beilstein-Institut
Subjects
Boron
Chemistry
difluoroalkylation
Hydrogen
Iodine
Letter
Light
Organic chemistry
organofluorine compounds
Radiation
radical addition
Sodium
visible light
China
Russia
difluoroalkylation
radical addition
visible light
organofluorine compounds
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Summary:A method for the reductive difluoroalkylation of electron-deficient alkenes using 1,1-difluorinated iodides mediated by irradiation with blue light is described. The reaction involves radical addition of 1,1-difluorinated radicals at the double bond followed by hydrogen atom transfer from sodium cyanoborohydride.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.14.139