Shear stress induces eNOS mRNA expression and improves endothelium-dependent dilation in senescent soleus muscle feed arteries

• Published in: Journal of applied physiology (1985) Vol. 98; no. 3; pp. 940 - 946
• Main Authors: Woodman, Christopher R, Price, Elmer M, Laughlin, M. Harold
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.03.2005; American Physiological Society
• Subjects: Aging - physiology; Animals; Arteries - cytology; Arteries - physiology; Biological and medical sciences; Blood Flow Velocity - physiology; Blood Pressure - physiology; Blood vessels; Circulatory system; Endothelium, Vascular - physiology; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - physiology; Mechanotransduction, Cellular - physiology; Muscle, Skeletal - blood supply; Muscle, Skeletal - metabolism; Muscular system; Nitric oxide; Nitric Oxide Synthase - metabolism; Nitric Oxide Synthase Type III; Rats; Rats, Inbred F344; Ribonucleic acid; RNA; RNA, Messenger - metabolism; Shear Strength; Stress; Stress, Mechanical; Striated muscle. Tendons; Vasodilation - physiology; Vertebrates: osteoarticular system, musculoskeletal system; Rat; Enzyme; Rodentia; real-time polymerase chain reaction; Gene expression; Soleus muscle; Real time; endothelial dysfunction; Artery; Nitric-oxide synthase; Vasodilation; Endothelium; Polymerase chain reaction; Vasomotricity; Vertebrata; Mammalia; Messenger RNA; Dysfunction; Blood vessel; Shear stress; Circulatory system; Oxidoreductases

Departments of Biomedical Sciences and Physiology and The Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri Submitted 15 April 2004 ; accepted in final form 28 October 2004 We tested the hypothesis that increased intraluminal shear stress induces endothelial nitric ox...