Coordinate regulation of carbohydrate metabolism and virulence by PtsH in pathogen Edwardsiella piscicida
Carbohydrate metabolism of bacterial pathogens conducts crucial roles in regulating pathogenesis but the molecular mechanisms by which metabolisms and virulence are been modulated and coordinated remain to be illuminated. Here, we investigated in this regard Edwardsiella piscicida , a notorious zoon...
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Published in | Applied microbiology and biotechnology Vol. 106; no. 5-6; pp. 2063 - 2077 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Berlin/Heidelberg
Springer Berlin Heidelberg
01.03.2022
Springer Springer Nature B.V |
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Abstract | Carbohydrate metabolism of bacterial pathogens conducts crucial roles in regulating pathogenesis but the molecular mechanisms by which metabolisms and virulence are been modulated and coordinated remain to be illuminated. Here, we investigated in this regard
Edwardsiella piscicida
, a notorious zoonotic pathogen previously named
E. tarda
that could ferment very few PTS sugars including glucose, fructose, mannose, N-acetylglucosamine, and N-acetylgalactosamine
.
We systematically characterized the roles of each of the predicted 23 components of phosphotransferase system (PTS) with the respective in-frame deletion mutants and defined medium containing specific PTS sugar. In addition, PtsH was identified as the crucial PTS component potentiating the utilization of all the tested PTS sugars. Intriguingly, we also found that PtsH while not Fpr was involved in T3SS gene expression and was essential for the pathogenesis of
E. piscicida
. To corroborate this, His15 and Ser46, the two established PtsH residues involved in phosphorylation cascade, showed redundant roles in regulating T3SS yields. Moreover, PtsH was shown to facilitate mannose uptake and transform it into mannose-6-phosphate, an allosteric substrate established to activate EvrA to augment bacterial virulence. Collectively, our observations provide new insights into the roles of PTS reciprocally regulating carbohydrate metabolism and virulence gene expression.
Key points
• PTS components’ roles for sugar uptake are systematically determined in Edwardsiella piscicida.
• PtsH is involved in saccharides uptake and in the regulation of E. piscicida’s T3SS expression.
• PtsH phosphorylation at His15 and Ser46 is essential for the T3SS expression and virulence. |
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AbstractList | Carbohydrate metabolism of bacterial pathogens conducts crucial roles in regulating pathogenesis but the molecular mechanisms by which metabolisms and virulence are been modulated and coordinated remain to be illuminated. Here, we investigated in this regard
Edwardsiella piscicida
, a notorious zoonotic pathogen previously named
E. tarda
that could ferment very few PTS sugars including glucose, fructose, mannose, N-acetylglucosamine, and N-acetylgalactosamine
.
We systematically characterized the roles of each of the predicted 23 components of phosphotransferase system (PTS) with the respective in-frame deletion mutants and defined medium containing specific PTS sugar. In addition, PtsH was identified as the crucial PTS component potentiating the utilization of all the tested PTS sugars. Intriguingly, we also found that PtsH while not Fpr was involved in T3SS gene expression and was essential for the pathogenesis of
E. piscicida
. To corroborate this, His15 and Ser46, the two established PtsH residues involved in phosphorylation cascade, showed redundant roles in regulating T3SS yields. Moreover, PtsH was shown to facilitate mannose uptake and transform it into mannose-6-phosphate, an allosteric substrate established to activate EvrA to augment bacterial virulence. Collectively, our observations provide new insights into the roles of PTS reciprocally regulating carbohydrate metabolism and virulence gene expression.
Key points
• PTS components’ roles for sugar uptake are systematically determined in Edwardsiella piscicida.
• PtsH is involved in saccharides uptake and in the regulation of E. piscicida’s T3SS expression.
• PtsH phosphorylation at His15 and Ser46 is essential for the T3SS expression and virulence. Carbohydrate metabolism of bacterial pathogens conducts crucial roles in regulating pathogenesis but the molecular mechanisms by which metabolisms and virulence are been modulated and coordinated remain to be illuminated. Here, we investigated in this regard Edwardsiella piscicida, a notorious zoonotic pathogen previously named E. tarda that could ferment very few PTS sugars including glucose, fructose, mannose, N-acetylglucosamine, and N-acetylgalactosamine. We systematically characterized the roles of each of the predicted 23 components of phosphotransferase system (PTS) with the respective in-frame deletion mutants and defined medium containing specific PTS sugar. In addition, PtsH was identified as the crucial PTS component potentiating the utilization of all the tested PTS sugars. Intriguingly, we also found that PtsH while not Fpr was involved in T3SS gene expression and was essential for the pathogenesis of E. piscicida. To corroborate this, His15 and Ser46, the two established PtsH residues involved in phosphorylation cascade, showed redundant roles in regulating T3SS yields. Moreover, PtsH was shown to facilitate mannose uptake and transform it into mannose-6-phosphate, an allosteric substrate established to activate EvrA to augment bacterial virulence. Collectively, our observations provide new insights into the roles of PTS reciprocally regulating carbohydrate metabolism and virulence gene expression. KEY POINTS: • PTS components' roles for sugar uptake are systematically determined in Edwardsiella piscicida. • PtsH is involved in saccharides uptake and in the regulation of E. piscicida's T3SS expression. • PtsH phosphorylation at His15 and Ser46 is essential for the T3SS expression and virulence. Abstract Carbohydrate metabolism of bacterial pathogens conducts crucial roles in regulating pathogenesis but the molecular mechanisms by which metabolisms and virulence are been modulated and coordinated remain to be illuminated. Here, we investigated in this regard Edwardsiella piscicida, a notorious zoonotic pathogen previously named E. tarda that could ferment very few PTS sugars including glucose, fructose, mannose, N-acetylglucosamine, and N-acetylgalactosamine. We systematically characterized the roles of each of the predicted 23 components of phosphotransferase system (PTS) with the respective in-frame deletion mutants and defined medium containing specific PTS sugar. In addition, PtsH was identified as the crucial PTS component potentiating the utilization of all the tested PTS sugars. Intriguingly, we also found that PtsH while not Fpr was involved in T3SS gene expression and was essential for the pathogenesis of E. piscicida. To corroborate this, His15 and Ser46, the two established PtsH residues involved in phosphorylation cascade, showed redundant roles in regulating T3SS yields. Moreover, PtsH was shown to facilitate mannose uptake and transform it into mannose-6-phosphate, an allosteric substrate established to activate EvrA to augment bacterial virulence. Collectively, our observations provide new insights into the roles of PTS reciprocally regulating carbohydrate metabolism and virulence gene expression.Key points• PTS components’ roles for sugar uptake are systematically determined in Edwardsiella piscicida.• PtsH is involved in saccharides uptake and in the regulation of E. piscicida’s T3SS expression.• PtsH phosphorylation at His15 and Ser46 is essential for the T3SS expression and virulence. Carbohydrate metabolism of bacterial pathogens conducts crucial roles in regulating pathogenesis but the molecular mechanisms by which metabolisms and virulence are been modulated and coordinated remain to be illuminated. Here, we investigated in this regard Edwardsiella piscicida, a notorious zoonotic pathogen previously named E. tarda that could ferment very few PTS sugars including glucose, fructose, mannose, N-acetylglucosamine, and N-acetylgalactosamine. We systematically characterized the roles of each of the predicted 23 components of phosphotransferase system (PTS) with the respective in-frame deletion mutants and defined medium containing specific PTS sugar. In addition, PtsH was identified as the crucial PTS component potentiating the utilization of all the tested PTS sugars. Intriguingly, we also found that PtsH while not Fpr was involved in T3SS gene expression and was essential for the pathogenesis of E. piscicida. To corroborate this, His15 and Ser46, the two established PtsH residues involved in phosphorylation cascade, showed redundant roles in regulating T3SS yields. Moreover, PtsH was shown to facilitate mannose uptake and transform it into mannose-6-phosphate, an allosteric substrate established to activate EvrA to augment bacterial virulence. Collectively, our observations provide new insights into the roles of PTS reciprocally regulating carbohydrate metabolism and virulence gene expression. |
Audience | Academic |
Author | Wu, Xiao Ma, Yue Zhang, Yuanxing Jiang, Jihao Xu, Rongjing Wang, Qiyao Shao, Shuai Mao, Qiaoqiao |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35218391$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_resmic_2023_104169 crossref_primary_10_3390_foods11172680 crossref_primary_10_1016_j_aquaculture_2022_739092 crossref_primary_10_1016_j_ijantimicag_2023_106925 |
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Copyright | The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. COPYRIGHT 2022 Springer The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. |
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Keywords | Mannose Type III secretion system (T3SS) Virulence Phosphotransferase system Edwardsiella piscicida |
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Snippet | Carbohydrate metabolism of bacterial pathogens conducts crucial roles in regulating pathogenesis but the molecular mechanisms by which metabolisms and... Abstract Carbohydrate metabolism of bacterial pathogens conducts crucial roles in regulating pathogenesis but the molecular mechanisms by which metabolisms and... |
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SubjectTerms | Allosteric properties Analysis Applied Genetics and Molecular Biotechnology Bacterial Proteins - genetics Bacterial Proteins - metabolism Biomedical and Life Sciences Biotechnology Carbohydrate Metabolism Carbohydrates Composition Deletion mutant Edwardsiella Edwardsiella piscicida Enterobacter Enterobacteriaceae Enterobacteriaceae Infections - veterinary Gene deletion Gene expression Genetic aspects Humans Identification and classification Life Sciences Mannose Metabolism Microbial Genetics and Genomics Microbiology Molecular modelling N-Acetylgalactosamine N-Acetylglucosamine Pathogenesis Pathogens Phosphorylation Phosphotransferase Phosphotransferases Properties Saccharides Substrates Sugar Type III Secretion Systems - genetics Virulence Virulence (Microbiology) |
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Title | Coordinate regulation of carbohydrate metabolism and virulence by PtsH in pathogen Edwardsiella piscicida |
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