Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial

• Published in: Scientific reports Vol. 14; no. 1; pp. 8833 - 12
• Main Authors: Sloshower, Jordan, Zeifman, Richard J., Guss, Jeffrey, Krause, Robert, Safi-Aghdam, Hamideh, Pathania, Surbhi, Pittman, Brian, D’Souza, Deepak Cyril
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/409; 692/699/476/1414; 692/700/565/1436/1437; Acceptance and Commitment Therapy; Clinical trials; Depression - drug therapy; Depressive Disorder, Major - drug therapy; Flexibility; Hallucinogens; Humanities and Social Sciences; Humans; Mental depression; Mental disorders; Mindfulness; multidisciplinary; Placebos; Psilocybin; Psychotherapy; Science; Science (multidisciplinary)

Several phase II studies have demonstrated that psilocybin-assisted therapy shows therapeutic potential across a spectrum of neuropsychiatric conditions, including major depressive disorder (MDD). However, the mechanisms underlying its often persisting beneficial effects remain unclear. Observationa...