Poly(l-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization

• Published in: Bioactive materials Vol. 6; no. 9; pp. 2688 - 2697
• Main Authors: Jiang, Zhongyu, Feng, Xiangru, Zou, Haoyang, Xu, Weiguo, Zhuang, Xiuli
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.09.2021; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Detachable PEGylation; Enhanced cell uptake; Platinum chemotherapy; Poly(l-glutamic acid); Prolonged circulation time; Prolonged circulation time; Detachable PEGylation; Platinum chemotherapy; Enhanced cell uptake; Poly(l-glutamic acid)

PEGylation has been widely applied to prolong the circulation times of nanomedicines via the steric shielding effect, which consequently improves the intratumoral accumulation. However, cell uptake of PEGylated nanoformulations is always blocked by the steric repulsion of PEG, which limits their the...