The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium

• Published in: Nature communications Vol. 14; no. 1; pp. 6885 - 18
• Main Authors: Shu, Zhaoqi, Fan, Minghe, Tu, Bo, Tang, Zhiheng, Wang, Haojie, Li, Haimeng, Li, Hengchao, Yuan, Meng, Bai, Jingru, Huo, Sihan, Wang, Lina, Zhu, Wei-Guo, Wang, Wei, Liu, Xiaoyun, Shu, Shaokun, Zhao, Ying
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/109; 13/21; 13/51; 38/15; 38/39; 38/70; 38/91; 45/77; 631/67/1504/1713; 631/80/86/2368; 692/4028/67/327; 82/80; 96/95; Adenocarcinoma; Animals; Cancer; Cancer-Associated Fibroblasts - metabolism; Carcinoma, Pancreatic Ductal - pathology; Cell Line, Tumor; Epithelial cells; Epithelium; Epithelium - metabolism; Fibroblasts; Fibroblasts - metabolism; Humanities and Social Sciences; Mice; multidisciplinary; Pancreas; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - pathology; Proprotein Convertase 9 - metabolism; Science; Science (multidisciplinary); Signal transduction; Stroma; Tumor cells; Tumor Microenvironment; Tumors; Weight reduction; Wnt protein

Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment (TME) is important for tumor development. Here we show that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Lin2...