Vortioxetine’s impact on the autonomic nervous system in depressed children and adolescents: analysis of the heart rate variability

• Published in: Scientific reports Vol. 14; no. 1; pp. 14442 - 11
• Main Authors: Krivosova, Michaela, Hutka, Peter, Ondrejka, Igor, Visnovcova, Zuzana, Funakova, Dana, Hrtanek, Igor, Ferencova, Nikola, Mlyncekova, Zuzana, Kovacova, Veronika, Macejova, Andrea, Kukucka, Tomas, Mokry, Juraj, Tonhajzerova, Ingrid
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.06.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378; 631/378/1457; 631/378/1457/1601; 631/378/1457/1945; 631/378/1959; 631/378/1959/1315; 631/477/2811; Adolescent; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Autonomic nervous system; Autonomic Nervous System - drug effects; Autonomic Nervous System - physiopathology; Child; Depression - drug therapy; Depression - physiopathology; Female; Heart rate; Heart Rate - drug effects; Humanities and Social Sciences; Humans; Hyperactivity; Male; Mental depression; multidisciplinary; Nervous system; Parasympathetic nervous system; Patients; Pediatrics; Pilot Projects; Polysomnography; REM sleep; Science; Science (multidisciplinary); Sleep; Sleep and wakefulness; Solitary tract nucleus; Vortioxetine - pharmacology

Relationship between depressive disorder and autonomic nervous system has been already discussed. Reduced emotional regulation is supposed to be associated with prefrontal hypofunction and subcortical hyperactivity. The aim of this study was to determine the effect of vortioxetine on heart rate vari...