DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease

• Published in: Journal of psychiatric research Vol. 92; pp. 74 - 80
• Main Authors: Ozaki, Yuki, Yoshino, Yuta, Yamazaki, Kiyohiro, Sao, Tomoko, Mori, Yoko, Ochi, Shinichiro, Yoshida, Taku, Mori, Takaaki, Iga, Jun-ichi, Ueno, Shu-ichi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2017
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Case-Control Studies; CpG Islands - genetics; DNA Methylation - genetics; Female; Gene Expression - genetics; Humans; Introns - genetics; Male; Membrane Glycoproteins - genetics; Polymorphism, Single Nucleotide - genetics; Psychiatry; Receptors, Immunologic - genetics; RNA, Messenger - metabolism; ROC Curve

Recent genome-wide association studies revealed that Triggering receptor expressed on myeloid cells 2 (TREM2) was associated with Alzheimer's disease (AD) and other neurodegenerative diseases. We previously reported that TREM2 mRNA is highly expressed in leukocytes of AD patients compared to th...