The role of TERT C228T and KDM6A alterations and TME in NMIBC treated with BCG

• Published in: NPJ precision oncology Vol. 8; no. 1; pp. 216 - 13
• Main Authors: Xia, Qi-Dong, Sun, Jian-Xuan, Yao, Zhi-Peng, Lu, Jun-Lin, Liu, Chen-Qian, Xu, Jin-Zhou, An, Ye, Xu, Meng-Yao, Zhang, Si-Han, Zhong, Xing-Yu, Zeng, Na, Ma, Si-Yang, He, Hao-Dong, Hu, Heng-Long, Hu, Jia, Lu, Yi, Li, Bing, Chen, Yao-Bing, Liu, Zheng, Wang, Shao-Gang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67/589/1336; 631/67/69; Biomarkers; Bladder cancer; Cancer Research; Chemotherapy; Gene Therapy; Hospitals; Human Genetics; Internal Medicine; Medicine; Medicine & Public Health; Mutation; Oncology; Urology
• ISSN: 2397-768X; 2397-768X
• DOI: 10.1038/s41698-024-00725-4

We aimed to investigate the genomic and tumor microenvironmental (TME) profiles in non-muscle invasive bladder cancer (NMIBC) and explore potential predictive markers for Bacillus Calmette–Guérin (BCG) treatment response in high-risk NMIBC patients (according to European Association of Urology (EAU)...