Control of cyclic oligoadenylate synthesis in a type III CRISPR system - Rouillon, Christophe; Athukoralage, Januka S; Graham, Shirley; Grüschow, Sabine; White, Malcolm F (eLife, 2018)
Keywords: Adaptive immunity; Adenine Nucleotides - biosynthesis; Antiviral drugs; archaea; Biochemistry and Chemical Biology; Cas10; Chromatography; Clustered Regularly Interspaced Short Palindromic Repeats; CRISPR; CRISPR-Cas Systems; cyclic oligoadenylate; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Endodeoxyribonucleases - genetics; Endodeoxyribonucleases - metabolism; Endoribonucleases - genetics; Endoribonucleases - metabolism; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Gene expression; Genomes; Kinetics; Mass spectrometry; Nuclease; Oligoribonucleotides - biosynthesis; Phosphorothioate; Phosphorothioate Oligonucleotides - pharmacology; Prokaryotes; Proteins; Ribonucleic acid; RNA; RNA Cleavage; RNA modification; RNA viruses; RNA Viruses - genetics; RNA Viruses - metabolism; RNA, Viral - genetics; RNA, Viral - metabolism; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Scientific imaging; Sulfolobus solfataricus; Sulfolobus solfataricus - drug effects; Sulfolobus solfataricus - genetics; Sulfolobus solfataricus - immunology; Sulfolobus solfataricus - metabolism; Time Factors; Transcription factors; Viral infections; CRISPR; chemical biology; biochemistry; Cas10; Sulfolobus solfataricus; cyclic oligoadenylate; archaea