Ubiquinol attenuates γ-radiation induced coronary and aortic changes via PDGF/p38 MAPK/ICAM-1 related pathway

• Published in: Scientific reports Vol. 13; no. 1; p. 22959
• Main Authors: El-Sabbagh, Walaa A., Fadel, Noha A., El-Hazek, Rania M., Osman, Ahmed H., Ramadan, Laila A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.12.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154; 631/45; 631/80/79; 631/80/86; 8-Hydroxydeoxyguanosine; Animals; Aorta; Cell adhesion; Cell Adhesion Molecules; Cholesterol; DNA damage; Endothelial cells; Endothelial Cells - metabolism; Gelatinase B; Gene expression; Humanities and Social Sciences; Intercellular adhesion molecule 1; Intercellular Adhesion Molecule-1 - metabolism; Irradiation; Kinases; Low density lipoprotein; Male; MAP kinase; Matrix metalloproteinase; Matrix Metalloproteinase 9; Metalloproteinase; Mitogen-Activated Protein Kinase 14; multidisciplinary; p38 Mitogen-Activated Protein Kinases - metabolism; Platelet-derived growth factor; Platelet-Derived Growth Factor - pharmacology; Post-irradiation; Radiation; Radiation therapy; Rats; Science; Science (multidisciplinary); Triglycerides; Ubiquinol; γ Radiation

Endothelial vascular injury is one of the most pivotal disorders emerging during radiotherapy. It is crucial to rely on strong antioxidants to defend against vascular damage. The current study was carried out to investigate the ameliorative effect of ubiquinol (Ubq) against gamma (γ)-radiation induc...