Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties

• Published in: NPJ systems biology and applications Vol. 10; no. 1; pp. 20 - 13
• Main Authors: van Genderen, Maisa N. G., Kneppers, Jeroen, Zaalberg, Anniek, Bekers, Elise M., Bergman, Andries M., Zwart, Wilbert, Eduati, Federica
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/553; 631/67; 692/4028; Androgen Antagonists; Androgen receptors; Androgens; Bioinformatics; Biomedical and Life Sciences; Castration; Cell interactions; Cell proliferation; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Fibroblasts; Growth patterns; Humans; Immunomodulation; Immunomodulators; Inflammation; Life Sciences; Macrophages; Male; Prostate - pathology; Prostate cancer; Prostatic Neoplasms, Castration-Resistant - metabolism; Prostatic Neoplasms, Castration-Resistant - pathology; Receptors, Androgen - metabolism; Systems Analysis; Systems Biology; Tumor cells; Tumor Microenvironment; Tumors

Inhibiting androgen receptor (AR) signaling through androgen deprivation therapy (ADT) reduces prostate cancer (PCa) growth in virtually all patients, but response may be temporary, in which case resistance develops, ultimately leading to lethal castration-resistant prostate cancer (CRPC). The tumor...