Nanomechanical action opens endo-lysosomal compartments

• Published in: Nature communications Vol. 14; no. 1; pp. 6645 - 11
• Main Authors: Zhao, Yu, Ye, Zhongfeng, Song, Donghui, Wich, Douglas, Gao, Shuliang, Khirallah, Jennifer, Xu, Qiaobing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 42; 631/61/54; 631/67/1059; 639/166/985; 639/301/54; 639/638/439; Animals; Anticancer properties; Antigen (tumor-associated); Antigens; Azo compounds; Biological products; Biological Products - metabolism; Biological Transport; Compartments; Cytoplasm; Dendritic cells; Destabilization; Humanities and Social Sciences; Intracellular; Irradiation; Light; Light irradiation; Lipids; Lysosomes - metabolism; Melanoma; Membranes; Mice; Molecular machines; multidisciplinary; Nucleic acids; Photons; Proteins; Radiation; Science; Science (multidisciplinary); Ultraviolet radiation

Endo-lysosomal escape is a highly inefficient process, which is a bottleneck for intracellular delivery of biologics, including proteins and nucleic acids. Herein, we demonstrate the design of a lipid-based nanoscale molecular machine, which achieves efficient cytosolic transport of biologics by des...