Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma

• Published in: Nature communications Vol. 14; no. 1; pp. 1839 - 24
• Main Authors: Chen, Zhihong, Soni, Nishant, Pinero, Gonzalo, Giotti, Bruno, Eddins, Devon J., Lindblad, Katherine E., Ross, James L., Puigdelloses Vallcorba, Montserrat, Joshi, Tanvi, Angione, Angelo, Thomason, Wes, Keane, Aislinn, Tsankova, Nadejda M., Gutmann, David H., Lira, Sergio A., Lujambio, Amaia, Ghosn, Eliver E. B., Tsankov, Alexander M., Hambardzumyan, Dolores
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.04.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/21; 13/51; 14/63; 38/77; 38/91; 49/31; 631/67/327; 631/67/580; 64/60; 692/4028/67/1922; Animal models; Animals; Brain cancer; Brain Neoplasms - pathology; Cancer; Carcinoma, Hepatocellular - metabolism; Cell Line, Tumor; CRISPR; Depletion; Gene sequencing; Genetic engineering; Genome editing; Genomes; Genotypes; Glioblastoma; Glioblastoma - pathology; Hepatocellular carcinoma; Humanities and Social Sciences; Hypoxia; Immune system; Infiltration; Leukocytes (neutrophilic); Liver cancer; Liver Neoplasms - metabolism; Metastases; Mice; Monocytes; Monocytes - metabolism; multidisciplinary; Myeloid cells; Neutrophils; Neutrophils - metabolism; Proteins; Proto-Oncogene Proteins c-sis - metabolism; Science; Science (multidisciplinary); Survival; Tumor microenvironment; Tumor necrosis factor-α; Tumors

Myeloid cells comprise the majority of immune cells in tumors, contributing to tumor growth and therapeutic resistance. Incomplete understanding of myeloid cells response to tumor driver mutation and therapeutic intervention impedes effective therapeutic design. Here, by leveraging CRISPR/Cas9-based...