The rate of dasotraline brain entry is slow following intravenous administration - Lew, Robert; Constantinescu, Cristian C.; Holden, Daniel; Carson, Richard E.; Carroll, Vincent; Galluppi, Gerald; Koblan, Kenneth S.; Hopkins, Seth C. (Psychopharmacology, 2020)
Keywords: 1-Naphthylamine - administration & dosage; 1-Naphthylamine - analogs & derivatives; 1-Naphthylamine - metabolism; Administration, Intravenous; Analysis; Animals; Biomedical and Life Sciences; Biomedicine; Blood-brain barrier; Brain - drug effects; Brain - metabolism; Chemical reaction, Rate of; Dopamine; Dopamine - metabolism; Dopamine D2 receptors; Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors; Dopamine Plasma Membrane Transport Proteins - metabolism; Dopamine transporter; Dopamine Uptake Inhibitors - administration & dosage; Dopamine Uptake Inhibitors - metabolism; Drug abuse; Female; Intravenous administration; Macaca mulatta; Male; Methylphenidate; Methylphenidate - administration & dosage; Methylphenidate - metabolism; Neostriatum; Neurosciences; Noradrenaline; Norepinephrine; Original Investigation; Pharmacodynamics; Pharmacology/Toxicology; Positron emission tomography; Positron-Emission Tomography - methods; Psychiatry; Raclopride; Receptors, Dopamine D2 - metabolism; Recreational drugs; United States; Dopamine; Nonhuman primate; Dopamine transporter; [; F]-FE-PE2I; PET; C]-Raclopride; [18F]-FE-PE2I; [11C]-Raclopride