Attention-Deficit/Hyperactivity Disorder–like Phenotype in a Mouse Model with Impaired Actin Dynamics

• Published in: Biological psychiatry (1969) Vol. 78; no. 2; pp. 95 - 106
• Main Authors: Zimmermann, Anika-Maria, Jene, Tanja, Wolf, Michael, Görlich, Andreas, Gurniak, Christine B, Sassoè-Pognetto, Marco, Witke, Walter, Friauf, Eckhard, Rust, Marco B
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.07.2015
• Subjects: Actin dynamics; ADF; ADHD; Animals; Attention Deficit Disorder with Hyperactivity - genetics; Attention Deficit Disorder with Hyperactivity - physiopathology; Attention Deficit Disorder with Hyperactivity - psychology; Central Nervous System Stimulants - pharmacology; Cofilin 1 - genetics; Cofilin 1 - metabolism; Cofilin 1 - physiology; Corpus Striatum - ultrastructure; Destrin - genetics; Destrin - physiology; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism; Dopamine Antagonists; Excitatory Postsynaptic Potentials; Glutamates - metabolism; Hyperactivity; Impulsive Behavior - drug effects; Impulsive Behavior - physiology; Locomotion; Male; Memory, Short-Term - physiology; Methylphenidate - pharmacology; Mice; Mice, Knockout; Motor Activity - genetics; n-cofilin; Nesting Behavior; Neurons - metabolism; Neurons - ultrastructure; Phenotype; Psychiatry; Receptors, Dopamine - physiology; Substantia Nigra - metabolism; Synapses - ultrastructure; ADHD; Locomotion; ADF; Hyperactivity; n-cofilin; Actin dynamics

Abstract Background Actin depolymerizing proteins of the actin depolymerizing factor (ADF)/cofilin family are essential for actin dynamics, which is critical for synaptic function. Two ADF/cofilin family members, ADF and n-cofilin, are highly abundant in the brain, where they are present in excitato...