Directed functional connectivity of the default-mode-network of young and older healthy subjects

• Published in: Scientific reports Vol. 14; no. 1; pp. 4304 - 14
• Main Authors: Goelman, Gadi, Dan, Rotem, Bezdicek, Ondrej, Jech, Robert, Ekstein, Dana
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/2611; 631/378/2612; 631/378/2629; 631/378/3920; 692/617; Aged; Aging; Alzheimer's disease; Brain - diagnostic imaging; Brain Mapping - methods; Cortex (cingulate); Default mode network; Directed functional connectivity MRI; Executive function; Functional magnetic resonance imaging; Healthy Volunteers; Humanities and Social Sciences; Humans; Long term memory; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Memory; Memory, Short-Term; multidisciplinary; Multivariate analysis; Neural networks; Neural Pathways; Neuropsychological tests; Neuropsychology; Physical activity; Science; Science (multidisciplinary); Sensory neurons; Short term memory; Somatosensory cortex; Spatial memory; Aging; Default mode network; Multivariate analysis; Neuropsychological tests; Directed functional connectivity MRI

Alterations in the default mode network (DMN) are associated with aging. We assessed age-dependent changes of DMN interactions and correlations with a battery of neuropsychological tests, to understand the differences of DMN directed connectivity between young and older subjects. Using a novel multi...