Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis

• Published in: Scientific reports Vol. 13; no. 1; p. 11177
• Main Authors: Ono, Gentaro, Kobayakawa, Kazu, Saiwai, Hirokazu, Tamaru, Tetsuya, Iura, Hirotaka, Haruta, Yohei, Kitade, Kazuki, Iida, Keiichiro, Kawaguchi, Kenichi, Matsumoto, Yoshihiro, Tsuda, Makoto, Tamura, Tomohiko, Ozato, Keiko, Inoue, Kazuhide, Konno, Dai-Jiro, Maeda, Takeshi, Okada, Seiji, Nakashima, Yasuharu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.07.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378; 631/378/2596; 631/378/2596/1308; 631/80/84; Adenosine diphosphate; Animals; Astrocytes; Bone marrow; Gliosis; Humanities and Social Sciences; Inflammation; Interferon Regulatory Factors; Leukocyte migration; Macrophages; Mice; multidisciplinary; Regeneration; Science; Science (multidisciplinary); Spinal Cord Injuries

After spinal cord injury (SCI), inflammatory cells such as macrophages infiltrate the injured area, and astrocytes migrate, forming a glial scar around macrophages. The glial scar inhibits axonal regeneration, resulting in significant permanent disability. However, the mechanism through which glial...