Impact of surface grafting density of PEG macromolecules on dually fluorescent silica nanoparticles used for the in vivo imaging of subcutaneous tumors

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 6; pp. 1587 - 1596
• Main Authors: Adumeau, Laurent, Genevois, Coralie, Roudier, Lydia, Schatz, Christophe, Couillaud, Franck, Mornet, Stéphane
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2017; Elsevier
• Subjects: Animals; Bioengineering; blood circulation; Cell Line, Tumor; Chemical Sciences; EPR effect; fluorescence; fluorescence emission spectroscopy; Fluorescence imaging; fluorescence microscopy; Fluorescent Dyes - administration & dosage; Fluorescent Dyes - chemistry; Fluorescent Dyes - metabolism; image analysis; Imaging; in vivo; Injections, Intravenous; intravenous injection; Life Sciences; liver; Luminescent Measurements; Male; Material chemistry; mice; Mice, Transgenic; Molecular Imaging - methods; monitoring; nanomedicine; Nanomedicine - methods; Nanoparticle; nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Nanoparticles - metabolism; Particle Size; PEGylation; Permeability; Polyethylene Glycols - chemistry; prostatic neoplasms; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; reflectance; silica; Silicon Dioxide - administration & dosage; Silicon Dioxide - chemistry; Silicon Dioxide - metabolism; subcutaneous injection; Surface Properties; Time Factors; Tissue Distribution; transmission electron microscopy; Tumor; zeta potential; RES; EDPS; DMSO; Nanoparticle; EPR; DLS; TFA; MPS; DL800; PEGylation; Tumor; in vivo; Fluorescence imaging; DCC; DL650; DRIFT; DCM; TGA; NPs; i.v; TEOS; PEG; NIR; EPR effect; FRI; TEM; BLI; biodistribution

In the context of systematically administered nanomedicines, the physicochemistry of NP surfaces must be controlled as a prerequisite to improve blood circulation time, and passive and active targeting. In particular, there is a real need to develop NP stealth and labelling for both in vivo and micr...