Mesenchymal stem cells in tumor microenvironment: drivers of bladder cancer progression through mitochondrial dynamics and energy production

• Published in: Cell death & disease Vol. 15; no. 9; pp. 688 - 14
• Main Authors: Yang, Enguang, Jing, Suoshi, Wang, Fang, Wang, Hanzhang, Fu, Shengjun, Yang, Li, Tian, Junqiang, Golijanin, Dragan J., El-Deiry, Wafik S., Cheng, Liang, Wang, Zhiping
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.09.2024; Springer Nature B.V; Nature Publishing Group
• Subjects: 692/699/67/327; 692/699/67/589/1336; Aged; Animals; Antibodies; Autophagy; Biochemistry; Biomedical and Life Sciences; Bladder cancer; Cell Biology; Cell Culture; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell size; Coculture Techniques; Disease Progression; Energy Metabolism; Female; Humans; Immunology; Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism; Kynurenine - metabolism; Life Sciences; Male; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Metastases; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitochondria; Mitochondria - metabolism; Mitochondrial Dynamics; Molecular modelling; Stem cell transplantation; Stem cells; Stroma; Tryptophan; Tumor Microenvironment; Tumors; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology

Mesenchymal stem cells (MSCs) in tumor microenvironment (TME) are crucial for the initiation, development, and metastasis of cancer. The impact and mechanism of MSCs on bladder cancer are uncertain. Here we analyzed 205 patient samples to explore the relationships between tumor-stroma ratio and clin...