Integrative temporal multi-omics reveals uncoupling of transcriptome and proteome during human T cell activation

• Published in: NPJ systems biology and applications Vol. 10; no. 1; pp. 21 - 13
• Main Authors: Weerakoon, Harshi, Mohamed, Ahmed, Wong, Yide, Chen, Jinjin, Senadheera, Bhagya, Haigh, Oscar, Watkins, Thomas S., Kazakoff, Stephen, Mukhopadhyay, Pamela, Mulvenna, Jason, Miles, John J., Hill, Michelle M., Lepletier, Ailin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250; 631/553; Bioinformatics; Biomedical and Life Sciences; CD28 antigen; CD3 antigen; CD4 antigen; CD8 antigen; Cell activation; Cell proliferation; Chemokines; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Cytotoxicity; Down-regulation; Glucose transport; Life Sciences; Lymphocytes; Lymphocytes T; Proteomes; Proteomics; Systems Biology; T cell receptors; Transcription factors; Transcriptomes; Transcriptomics

Engagement of the T cell receptor (TCR) triggers molecular reprogramming leading to the acquisition of specialized effector functions by CD4 helper and CD8 cytotoxic T cells. While transcription factors, chemokines, and cytokines are known drivers in this process, the temporal proteomic and transcri...