Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment

• Published in: Nature communications Vol. 14; no. 1; pp. 6257 - 18
• Main Authors: Vinikoor, Tra, Dzidotor, Godwin K., Le, Thinh T., Liu, Yang, Kan, Ho-Man, Barui, Srimanta, Chorsi, Meysam T., Curry, Eli J., Reinhardt, Emily, Wang, Hanzhang, Singh, Parbeen, Merriman, Marc A., D’Orio, Ethan, Park, Jinyoung, Xiao, Shuyang, Chapman, James H., Lin, Feng, Truong, Cao-Sang, Prasadh, Somasundaram, Chuba, Lisa, Killoh, Shaelyn, Lee, Seok-Woo, Wu, Qian, Chidambaram, Ramaswamy M., Lo, Kevin W. H., Laurencin, Cato T., Nguyen, Thanh D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/107; 631/61/2035; 639/301/54/990; 692/308/575; Analgesics; Animals; Anti-inflammatory agents; Arthritis; Biocompatibility; Biodegradability; Biodegradation; Biomaterials; Biomedical materials; Bone growth; Cartilage; Cartilage diseases; Cartilage, Articular; Cell migration; Cells, Cultured; Chondrogenesis; Collagen - chemistry; Healing; Humanities and Social Sciences; Humans; Hydrogels; Hydrogels - chemistry; Immunosuppressive agents; Inflammation; Joint diseases; Mechanical properties; multidisciplinary; Osteoarthritis; Osteogenesis; Piezoelectricity; Polylactic acid; Rabbits; Regeneration; Regeneration (physiology); Science; Science (multidisciplinary); Signs and symptoms; Stem cells; Subchondral bone; Tissue Engineering; Tissue Scaffolds - chemistry; Toxicity; Transforming growth factor-b1; Ultrasonic imaging; Ultrasound; Wound Healing

Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded insid...