Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment
Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded insid...
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| Published in | Nature communications Vol. 14; no. 1; pp. 6257 - 18 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
06.10.2023
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that the piezoelectric hydrogel with ultrasound can enhance cell migration and induce stem cells to secrete TGF-β1, which promotes chondrogenesis. In vivo, the rabbits with osteochondral critical-size defects receiving the ultrasound-activated piezoelectric hydrogel show increased subchondral bone formation, improved hyaline-cartilage structure, and good mechanical properties, close to healthy native cartilage. This piezoelectric hydrogel is not only useful for cartilage healing but also potentially applicable to other tissue regeneration, offering a significant impact on the field of regenerative tissue engineering.
The use of biomaterial scaffolds-based cartilage grafts could potentially innovate the Osteoarthritis (OA) treatment, but has been limited by toxicity concerns and invasive surgical procedures. Here, the authors report an injectable and biodegradable piezoelectric hydrogel with ultrasound activation to offer a minimally invasive approach for OA treatment. |
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| AbstractList | Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that the piezoelectric hydrogel with ultrasound can enhance cell migration and induce stem cells to secrete TGF-β1, which promotes chondrogenesis. In vivo, the rabbits with osteochondral critical-size defects receiving the ultrasound-activated piezoelectric hydrogel show increased subchondral bone formation, improved hyaline-cartilage structure, and good mechanical properties, close to healthy native cartilage. This piezoelectric hydrogel is not only useful for cartilage healing but also potentially applicable to other tissue regeneration, offering a significant impact on the field of regenerative tissue engineering.Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that the piezoelectric hydrogel with ultrasound can enhance cell migration and induce stem cells to secrete TGF-β1, which promotes chondrogenesis. In vivo, the rabbits with osteochondral critical-size defects receiving the ultrasound-activated piezoelectric hydrogel show increased subchondral bone formation, improved hyaline-cartilage structure, and good mechanical properties, close to healthy native cartilage. This piezoelectric hydrogel is not only useful for cartilage healing but also potentially applicable to other tissue regeneration, offering a significant impact on the field of regenerative tissue engineering. Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that the piezoelectric hydrogel with ultrasound can enhance cell migration and induce stem cells to secrete TGF-β1, which promotes chondrogenesis. In vivo, the rabbits with osteochondral critical-size defects receiving the ultrasound-activated piezoelectric hydrogel show increased subchondral bone formation, improved hyaline-cartilage structure, and good mechanical properties, close to healthy native cartilage. This piezoelectric hydrogel is not only useful for cartilage healing but also potentially applicable to other tissue regeneration, offering a significant impact on the field of regenerative tissue engineering. Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that the piezoelectric hydrogel with ultrasound can enhance cell migration and induce stem cells to secrete TGF-β1, which promotes chondrogenesis. In vivo, the rabbits with osteochondral critical-size defects receiving the ultrasound-activated piezoelectric hydrogel show increased subchondral bone formation, improved hyaline-cartilage structure, and good mechanical properties, close to healthy native cartilage. This piezoelectric hydrogel is not only useful for cartilage healing but also potentially applicable to other tissue regeneration, offering a significant impact on the field of regenerative tissue engineering. The use of biomaterial scaffolds-based cartilage grafts could potentially innovate the Osteoarthritis (OA) treatment, but has been limited by toxicity concerns and invasive surgical procedures. Here, the authors report an injectable and biodegradable piezoelectric hydrogel with ultrasound activation to offer a minimally invasive approach for OA treatment. Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that the piezoelectric hydrogel with ultrasound can enhance cell migration and induce stem cells to secrete TGF-β1, which promotes chondrogenesis. In vivo, the rabbits with osteochondral critical-size defects receiving the ultrasound-activated piezoelectric hydrogel show increased subchondral bone formation, improved hyaline-cartilage structure, and good mechanical properties, close to healthy native cartilage. This piezoelectric hydrogel is not only useful for cartilage healing but also potentially applicable to other tissue regeneration, offering a significant impact on the field of regenerative tissue engineering.The use of biomaterial scaffolds-based cartilage grafts could potentially innovate the Osteoarthritis (OA) treatment, but has been limited by toxicity concerns and invasive surgical procedures. Here, the authors report an injectable and biodegradable piezoelectric hydrogel with ultrasound activation to offer a minimally invasive approach for OA treatment. Abstract Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that the piezoelectric hydrogel with ultrasound can enhance cell migration and induce stem cells to secrete TGF-β1, which promotes chondrogenesis. In vivo, the rabbits with osteochondral critical-size defects receiving the ultrasound-activated piezoelectric hydrogel show increased subchondral bone formation, improved hyaline-cartilage structure, and good mechanical properties, close to healthy native cartilage. This piezoelectric hydrogel is not only useful for cartilage healing but also potentially applicable to other tissue regeneration, offering a significant impact on the field of regenerative tissue engineering. |
| ArticleNumber | 6257 |
| Author | Vinikoor, Tra Kan, Ho-Man Lee, Seok-Woo Nguyen, Thanh D. D’Orio, Ethan Chuba, Lisa Chorsi, Meysam T. Truong, Cao-Sang Wang, Hanzhang Chidambaram, Ramaswamy M. Killoh, Shaelyn Xiao, Shuyang Merriman, Marc A. Le, Thinh T. Prasadh, Somasundaram Dzidotor, Godwin K. Curry, Eli J. Lo, Kevin W. H. Liu, Yang Singh, Parbeen Wu, Qian Park, Jinyoung Lin, Feng Laurencin, Cato T. Reinhardt, Emily Barui, Srimanta Chapman, James H. |
| Author_xml | – sequence: 1 givenname: Tra orcidid: 0000-0002-7637-6296 surname: Vinikoor fullname: Vinikoor, Tra organization: Department of Biomedical Engineering, University of Connecticut, The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health – sequence: 2 givenname: Godwin K. surname: Dzidotor fullname: Dzidotor, Godwin K. organization: The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health, Department of Chemical & Biomolecular Engineering, University of Connecticut – sequence: 3 givenname: Thinh T. surname: Le fullname: Le, Thinh T. organization: Department of Mechanical Engineering, University of Connecticut – sequence: 4 givenname: Yang orcidid: 0000-0003-1655-828X surname: Liu fullname: Liu, Yang organization: Center of Digital Dentistry/Department of Prosthodontics/Central Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & NMPA Key Laboratory for Dental Materials – sequence: 5 givenname: Ho-Man surname: Kan fullname: Kan, Ho-Man organization: The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health – sequence: 6 givenname: Srimanta surname: Barui fullname: Barui, Srimanta organization: The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health – sequence: 7 givenname: Meysam T. orcidid: 0000-0002-2633-9200 surname: Chorsi fullname: Chorsi, Meysam T. organization: Department of Mechanical Engineering, University of Connecticut – sequence: 8 givenname: Eli J. orcidid: 0000-0001-8396-3037 surname: Curry fullname: Curry, Eli J. organization: Eli Lilly and Company, Department of Biomedical Engineering, University of Connecticut – sequence: 9 givenname: Emily surname: Reinhardt fullname: Reinhardt, Emily organization: Department of Pathobiology and Veterinary Science, University of Connecticut – sequence: 10 givenname: Hanzhang surname: Wang fullname: Wang, Hanzhang organization: Pathology and Laboratory Medicine, University of Connecticut Health Center – sequence: 11 givenname: Parbeen surname: Singh fullname: Singh, Parbeen organization: Department of Mechanical Engineering, University of Connecticut – sequence: 12 givenname: Marc A. orcidid: 0000-0003-2577-3045 surname: Merriman fullname: Merriman, Marc A. organization: The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health, Department of Chemical & Biomolecular Engineering, University of Connecticut – sequence: 13 givenname: Ethan orcidid: 0009-0004-5208-5357 surname: D’Orio fullname: D’Orio, Ethan organization: Department of Advanced Manufacturing for Energy Systems Engineering, University of Connecticut – sequence: 14 givenname: Jinyoung orcidid: 0000-0003-0943-3649 surname: Park fullname: Park, Jinyoung organization: Department of Biomedical Engineering, University of Connecticut – sequence: 15 givenname: Shuyang surname: Xiao fullname: Xiao, Shuyang organization: Department of Materials Science and Engineering & Institute of Materials Science, University of Connecticut – sequence: 16 givenname: James H. orcidid: 0000-0002-4750-9926 surname: Chapman fullname: Chapman, James H. organization: The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health – sequence: 17 givenname: Feng surname: Lin fullname: Lin, Feng organization: Department of Mechanical Engineering, University of Connecticut – sequence: 18 givenname: Cao-Sang surname: Truong fullname: Truong, Cao-Sang organization: Department of Biomedical Engineering, University of Connecticut – sequence: 19 givenname: Somasundaram surname: Prasadh fullname: Prasadh, Somasundaram organization: Center for Clean Energy Engineering, University of Connecticut – sequence: 20 givenname: Lisa surname: Chuba fullname: Chuba, Lisa organization: Center for Comparative Medicine, University of Connecticut Health Center – sequence: 21 givenname: Shaelyn surname: Killoh fullname: Killoh, Shaelyn organization: Center for Comparative Medicine, University of Connecticut Health Center – sequence: 22 givenname: Seok-Woo orcidid: 0000-0001-6752-5694 surname: Lee fullname: Lee, Seok-Woo organization: Department of Materials Science and Engineering & Institute of Materials Science, University of Connecticut, Institute of Materials Science, University of Connecticut – sequence: 23 givenname: Qian surname: Wu fullname: Wu, Qian organization: Pathology and Laboratory Medicine, University of Connecticut Health Center – sequence: 24 givenname: Ramaswamy M. surname: Chidambaram fullname: Chidambaram, Ramaswamy M. organization: Center for Comparative Medicine, University of Connecticut Health Center – sequence: 25 givenname: Kevin W. H. surname: Lo fullname: Lo, Kevin W. H. organization: The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health, Institute of Materials Science, University of Connecticut, Department of Medicine, University of Connecticut Health Center – sequence: 26 givenname: Cato T. orcidid: 0000-0001-6765-3047 surname: Laurencin fullname: Laurencin, Cato T. organization: Department of Biomedical Engineering, University of Connecticut, The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health, Department of Chemical & Biomolecular Engineering, University of Connecticut, Department of Materials Science and Engineering & Institute of Materials Science, University of Connecticut, Institute of Materials Science, University of Connecticut, Department of Orthopaedic Surgery University of Connecticut Health – sequence: 27 givenname: Thanh D. orcidid: 0000-0003-0813-4807 surname: Nguyen fullname: Nguyen, Thanh D. email: nguyentd@uconn.edu organization: Department of Biomedical Engineering, University of Connecticut, Department of Mechanical Engineering, University of Connecticut, Institute of Materials Science, University of Connecticut |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37802985$$D View this record in MEDLINE/PubMed |
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| Snippet | Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease.... Abstract Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this... |
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| SubjectTerms | 13/107 631/61/2035 639/301/54/990 692/308/575 Analgesics Animals Anti-inflammatory agents Arthritis Biocompatibility Biodegradability Biodegradation Biomaterials Biomedical materials Bone growth Cartilage Cartilage diseases Cartilage, Articular Cell migration Cells, Cultured Chondrogenesis Collagen - chemistry Healing Humanities and Social Sciences Humans Hydrogels Hydrogels - chemistry Immunosuppressive agents Inflammation Joint diseases Mechanical properties multidisciplinary Osteoarthritis Osteogenesis Piezoelectricity Polylactic acid Rabbits Regeneration Regeneration (physiology) Science Science (multidisciplinary) Signs and symptoms Stem cells Subchondral bone Tissue Engineering Tissue Scaffolds - chemistry Toxicity Transforming growth factor-b1 Ultrasonic imaging Ultrasound Wound Healing |
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| Title | Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment |
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