Identification of trypsin-degrading commensals in the large intestine

• Published in: Nature (London) Vol. 609; no. 7927; pp. 582 - 589
• Main Authors: Li, Youxian, Watanabe, Eiichiro, Kawashima, Yusuke, Plichta, Damian R., Wang, Zhujun, Ujike, Makoto, Ang, Qi Yan, Wu, Runrun, Furuichi, Munehiro, Takeshita, Kozue, Yoshida, Koji, Nishiyama, Keita, Kearney, Sean M., Suda, Wataru, Hattori, Masahira, Sasajima, Satoshi, Matsunaga, Takahiro, Zhang, Xiaoxi, Watanabe, Kazuto, Fujishiro, Jun, Norman, Jason M., Olle, Bernat, Matsuyama, Shutoku, Namkoong, Ho, Uwamino, Yoshifumi, Ishii, Makoto, Fukunaga, Koichi, Hasegawa, Naoki, Ohara, Osamu, Xavier, Ramnik J., Atarashi, Koji, Honda, Kenya
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.09.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 101/28; 13/1; 42/41; 631/250/347; 631/326/2565/2134; 64/60; 82/16; 82/29; 82/58; 82/83; Antibiotics; Autolysis; Citrobacter; Colonization; Commensals; Coronaviruses; Degradation; Diarrhea; Enzymes; Hepatitis; Homeostasis; Humanities and Social Sciences; Immunoglobulin A; Infections; Intestinal microflora; Intestine; Large intestine; Microbiomes; Microbiota; multidisciplinary; Pathogens; Polysaccharides; Proteins; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Trypsin; Viral diseases

Increased levels of proteases, such as trypsin, in the distal intestine have been implicated in intestinal pathological conditions 1 – 3 . However, the players and mechanisms that underlie protease regulation in the intestinal lumen have remained unclear. Here we show that Paraprevotella strains iso...