Combined pretreatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio predicts survival and prognosis in patients with non-metastatic nasopharyngeal carcinoma: a retrospective study

• Published in: Scientific reports Vol. 14; no. 1; pp. 9898 - 12
• Main Authors: Yang, Dong, Li, Pian, Meng, Zhen, Hu, Xueying, Huang, Zichong, Huang, Heqing, Dong, Huan, Qin, Yating, Chen, Cong, Chen, Xinghua, Li, Zhiru, Zhou, Ziyan, Li, Yi, Kang, Min
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67/1536; 692/4028/67; Adult; Aged; Blood Platelets - pathology; Carcinoma - blood; Carcinoma - mortality; Carcinoma - pathology; Female; Humanities and Social Sciences; Humans; Leukocytes (neutrophilic); Lymphocyte Count; Lymphocytes; Lymphocytes - pathology; Male; Medical prognosis; Metastases; Metastasis; Middle Aged; multidisciplinary; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - blood; Nasopharyngeal Carcinoma - mortality; Nasopharyngeal Carcinoma - pathology; Nasopharyngeal Neoplasms - blood; Nasopharyngeal Neoplasms - mortality; Nasopharyngeal Neoplasms - pathology; Neutrophil-lymphocyte ratio; Neutrophils; Neutrophils - pathology; Non-metastatic nasopharyngeal carcinoma; Patients; Platelet Count; Platelet-lymphocyte ratio; Platelets; Prognosis; Regression analysis; Retrospective Studies; Risk factors; ROC Curve; Science; Science (multidisciplinary); Survival; Throat cancer; Young Adult; Neutrophil-lymphocyte ratio; Non-metastatic nasopharyngeal carcinoma; Platelet-lymphocyte ratio; Prognosis; Survival
• DOI: 10.1038/s41598-024-59131-2
• ISSN: 2045-2322

The clinical significance of the combination of neutrophil–lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) is unclear. This study investigated the predictive value of pretreatment NLR (pre-NLR) combined with pretreatment PLR (pre-PLR) for the survival and prognosis of nasopharyngeal carcinoma (NPC). A total of 765 patients with non-metastatic NPC from two hospitals were retrospectively analyzed. The pre-NLR-PLR groups were as follows: HRG, high pre-NLR and high pre-PLR. MRG, high pre-NLR and low pre-PLR or low pre-NLR and high pre-PLR. LRG, neither high pre-NLR nor high pre-PLR. Receiver operating characteristic (ROC) curves were used to identify the cutoff-value and discriminant performance of the model. We compared survival rates and factors affecting the prognosis among different groups. The 5-year overall survival (OS), local regional recurrence-free survival (LRRFS) and distant metastasis-free survival (DMFS) of NPC patients in HRG were significantly poorer than those in MRG and LRG. The pre-NLR-PLR score was positively correlated with T stage, clinical stage, ECOG, and pathological classification. Multivariate cox regression analysis showed that pre-NLR-PLR scoring system, ECOG, pre-ALB, pre-CRP and pre-LMR were independent risk factors affecting 5-year OS, LRRFS and DMFS. The ROC curve showed that area under the curve (AUC) values of pre-NLR-PLR of 5-year OS, LRRFS and DMFS were higher than those of pre-NLR and pre-PLR. pre-NLR-PLR is an independent risk factor for the prognosis of NPC. The pre-NLR-PLR scoring system can be used as an individualized clinical assessment tool to predict the prognosis of patients with non-metastatic NPC more accurately and easily.