The inactive X chromosome accumulates widespread epigenetic variability with age

• Published in: Clinical epigenetics Vol. 15; no. 1; pp. 1 - 12
• Main Authors: Liu, Yunfeng, Sinke, Lucy, Jonkman, Thomas H., Slieker, Roderick C., van Zwet, Erik W., Daxinger, Lucia, Heijmans, Bastiaan T.
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 25.08.2023; BioMed Central; BMC
• Subjects: Age; Aging; Analysis; Atherosclerosis; Biobanks; Blood; CpG islands; Datasets; DNA methylation; Epigenetic inheritance; Epigenetics; Females; Gene expression; Generalized linear models; Genes; Genomes; Granulocytes; Males; Methylation; Monocytes; Quality control; Variance; Women; X chromosome; X chromosomes; X-chromosome inactivation; Netherlands; United States > US

Background Loss of epigenetic control is a hallmark of aging. Among the most prominent roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome in females through DNA methylation. Hence, age-related disruption of X-chromosome inactivation (XCI) may contribute to th...