FTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC - Li, Rong; Yan, Xijing; Xiao, Cuicui; Wang, Tingting; Li, Xuejiao; Hu, Zhongying; Liang, Jinliang; Zhang, Jiebin; Cai, Jianye; Sui, Xin; Liu, Qiuli; Wu, Manli; et al. (Nature communications, 2024)
Keywords: 13; 13/1; 13/2; 13/51; 14; 631/136/7; 631/80/82; 692/4020/4021/288/2032; 692/700/565/545/576/402; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - metabolism; Animals; Antigens, CD; Body fat; Cell death; Coenzyme A Ligases - genetics; Coenzyme A Ligases - metabolism; Down-regulation; Ferroptosis; Ferroptosis - genetics; Gene expression; Humanities and Social Sciences; Humans; Injury prevention; Ischemia; Liver; Liver - metabolism; Liver - pathology; Liver Transplantation; Liver transplants; Male; Mass spectrometry; Mass spectroscopy; Mice; Mice, Inbred C57BL; mRNA stability; multidisciplinary; Nicotinamide; Pathogenesis; Phenotypes; Receptors, Transferrin - genetics; Receptors, Transferrin - metabolism; Reperfusion; Reperfusion Injury - genetics; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; RNA Stability - genetics; Science; Science (multidisciplinary); Stability; Transferrin; Transplantation; Up-Regulation