Systematic detection of tertiary structural modules in large RNAs and RNP interfaces by Tb-seq

• Published in: Nature communications Vol. 14; no. 1; pp. 3426 - 11
• Main Authors: Patel, Shivali, Sexton, Alec N., Strine, Madison S., Wilen, Craig B., Simon, Matthew D., Pyle, Anna Marie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.06.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 45/91; 631/1647/2163; 631/1647/514/1949; 631/45/500; 631/45/535; 631/92/96; Cations; Cleavage; Gene expression; Humanities and Social Sciences; Interfaces; Magnesium; Modules; multidisciplinary; Next-generation sequencing; Phosphates; Ribonucleic acid; RNA; Science; Science (multidisciplinary); Structural members; Terbium; Transcriptomes

Compact RNA structural motifs control many aspects of gene expression, but we lack methods for finding these structures in the vast expanse of multi-kilobase RNAs. To adopt specific 3-D shapes, many RNA modules must compress their RNA backbones together, bringing negatively charged phosphates into c...