Cellular characterisation of advanced osteoarthritis knee synovium

• Published in: Arthritis research & therapy Vol. 25; no. 1; pp. 1 - 154
• Main Authors: Mimpen, Jolet Y, Hedley, Robert, Ridley, Anna, Baldwin, Mathew J, Windell, Dylan, Bhalla, Ananya, Ramos-Mucci, Lorenzo, Buckley, Christopher D, Coles, Mark C, Alvand, Abtin, Price, Andrew J, Carr, Andrew J, Dakin, Stephanie G, Snelling, Sarah J. B
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 23.08.2023; BioMed Central; BMC
• Subjects: Antigens; Arthritis; B cells; Cells; Development and progression; Diagnosis; Fibroblasts; Flow cytometry; Health aspects; Inflammation; Macrophages; Osteoarthritis; Pathophysiology; Physiological aspects; Rheumatoid arthritis; Synovial membranes; Synovium; T cells; United Kingdom; United Kingdom > UK; United States > US

Abstract Objectives Osteoarthritis (OA) is increasingly recognised as a whole joint disease, with an important role for synovium. However, the repertoire of immune cells and fibroblasts that constitute OA synovium remains understudied. This study aims to characterise the cellular composition of adva...