Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing

• Published in: Bioactive materials Vol. 10; pp. 460 - 473
• Main Authors: He, Siqi, Walimbe, Tanaya, Chen, Hongyuan, Gao, Kewa, Kumar, Priyadarsini, Wei, Yifan, Hao, Dake, Liu, Ruiwu, Farmer, Diana L., Lam, Kit S., Zhou, Jianda, Panitch, Alyssa, Wang, Aijun
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.04.2022; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Diabetic ischemic wound; ECM scaffold; Endothelial progenitor cells; Neovascularization; Wound healing; ECM scaffold; Wound healing; Neovascularization; Diabetic ischemic wound; Endothelial progenitor cells

Diabetic ischemic wound treatment remains a critical clinical challenge. Neovascularization plays a significant role in wound healing during all stages of the tissue repair process. Strategies that enhance angiogenesis and neovascularization and improve ischemic pathology may promote the healing of...