Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury

• Published in: Experimental neurology Vol. 265; pp. 84 - 93
• Main Authors: Wang, Wang-Xia, Visavadiya, Nishant P., Pandya, Jignesh D., Nelson, Peter T., Sullivan, Patrick G., Springer, Joe E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2015
• Subjects: Animals; Brain Injuries - metabolism; Brain Injuries - pathology; Cells, Cultured; Controlled cortical impact; Cytoplasm - metabolism; Cytoplasm - pathology; Hippocampus; Hippocampus - metabolism; Hippocampus - pathology; Inflammation; Male; MicroRNA; MicroRNAs - biosynthesis; MiR-142-3p; MiR-142-5p; MiR-146a; MiR-150; MiR-155; MiR-223; Mitochondria; Mitochondria - metabolism; Rats; Rats, Sprague-Dawley; Traumatic brain injury; MiR-142-3p; MiR-150; Mitochondria; MiR-142-5p; MiR-146a; MicroRNA; Traumatic brain injury; Controlled cortical impact; MiR-223; Inflammation; Hippocampus; MiR-155

Traumatic brain injury (TBI) is a major cause of death and disability. However, the molecular events contributing to the pathogenesis are not well understood. Mitochondria serve as the powerhouse of cells, respond to cellular demands and stressors, and play an essential role in cell signaling, diffe...