An in vitro model of the macrophage-endothelial interface to characterize CAR T-cell induced cytokine storm

• Published in: Scientific reports Vol. 13; no. 1; p. 18835
• Main Authors: Rosen, Robert S., Yang, Jason H., Peña, Juan S., Schloss, Rene, Yarmush, Martin L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/61/51/1844; 692/4028/67/1059/2325; 692/420/256/2516; 692/699/249/2510; 692/700/565/2194; Cell therapy; Chimeric antigen receptors; Corticoids; Corticosteroids; Cytokine Release Syndrome; Cytokine storm; Endothelial Cells; Humanities and Social Sciences; Humans; Inflammation; Inflammation - drug therapy; Lymphocytes B; Lymphocytes T; Macrophages; Malignancy; multidisciplinary; Receptors, Antigen, T-Cell; Receptors, Chimeric Antigen; Science; Science (multidisciplinary); Stat3 protein; T-Lymphocytes; Toxicity

Chimeric Antigen Receptor (CAR) T-cell therapy is a highly effective treatment for B-cell malignancies but limited in use due to clinically significant hyperinflammatory toxicities. Understanding the pathophysiologic mechanisms which mediate these toxicities can help identify novel management strate...