Chronic Low-Grade Inflammation in Elderly Persons Is Associated with Altered Tryptophan and Tyrosine Metabolism: Role in Neuropsychiatric Symptoms
Neuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of aging, plays a role. Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxyge...
Saved in:
| Published in | Biological psychiatry (1969) Vol. 70; no. 2; pp. 175 - 182 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
15.07.2011
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Neuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of aging, plays a role. Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxygenase (IDO) and the guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis of monoamines. The present study assessed this possibility in 284 healthy elderly subjects drawn from the Three-City cohort.
Assays included the measurement of serum interleukin-6 and C-reactive-protein, as inflammatory markers; tryptophan, kynurenine, and their ratio as index of IDO activity; and neopterin, phenylalanine, tyrosine, and nitrite, as markers of GTP-CH1 activity. In addition, structured assessments of depressive symptomatology, fatigue, and general behavioral/neurovegetative symptoms were performed.
As expected, age correlated significantly with concentrations of immune markers and neuropsychiatric symptoms. Increased inflammation was related to reduced tryptophan concentrations and increased kynurenine levels, suggestive of IDO-induced increased tryptophan catabolism. In addition, inflammation was associated with increases in neopterin and nitrite levels and in phenylalanine concentrations at the expense of tyrosine. Interestingly, increased tryptophan catabolism was associated with the depressive symptoms of lassitude, reduced motivation, anorexia, and pessimism. In contrast, variations in markers of GTP-CH1 activity correlated more with neurovegetative symptoms, including sleep disturbance, digestive symptoms, fatigue, sickness, and motor symptoms.
These findings show that chronic low-grade inflammation in aging is associated with alterations in enzymatic pathways involved in monoamine metabolism and suggest that these alterations might participate in the pathophysiology of neuropsychiatric symptoms in elderly persons. |
|---|---|
| AbstractList | *BACKGROUND : Neuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of aging, plays a role. Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxygenase (IDO) and the guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis of monoamines. The present study assessed this possibility in 284 healthy elderly subjects drawn from the Three-City cohort. *METHODS : Assays included the measurement of serum interleukin-6 and C-reactive-protein, as inflammatory markers; tryptophan, kynurenine, and their ratio as index of IDO activity; and neopterin, phenylalanine, tyrosine, and nitrite, as markers of GTP-CH1 activity. In addition, structured assessments of depressive symptomatology, fatigue, and general behavioral/neurovegetative symptoms were performed. *RESULTS : As expected, age correlated significantly with concentrations of immune markers and neuropsychiatric symptoms. Increased inflammation was related to reduced tryptophan concentrations and increased kynurenine levels, suggestive of IDO-induced increased tryptophan catabolism. In addition, inflammation was associated with increases in neopterin and nitrite levels and in phenylalanine concentrations at the expense of tyrosine. Interestingly, increased tryptophan catabolism was associated with the depressive symptoms of lassitude, reduced motivation, anorexia, and pessimism. In contrast, variations in markers of GTP-CH1 activity correlated more with neurovegetative symptoms, including sleep disturbance, digestive symptoms, fatigue, sickness, and motor symptoms. *CONCLUSIONS : These findings show that chronic low-grade inflammation in aging is associated with alterations in enzymatic pathways involved in monoamine metabolism and suggest that these alterations might participate in the pathophysiology of neuropsychiatric symptoms in elderly persons. Neuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of aging, plays a role. Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxygenase (IDO) and the guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis of monoamines. The present study assessed this possibility in 284 healthy elderly subjects drawn from the Three-City cohort.BACKGROUNDNeuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of aging, plays a role. Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxygenase (IDO) and the guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis of monoamines. The present study assessed this possibility in 284 healthy elderly subjects drawn from the Three-City cohort.Assays included the measurement of serum interleukin-6 and C-reactive-protein, as inflammatory markers; tryptophan, kynurenine, and their ratio as index of IDO activity; and neopterin, phenylalanine, tyrosine, and nitrite, as markers of GTP-CH1 activity. In addition, structured assessments of depressive symptomatology, fatigue, and general behavioral/neurovegetative symptoms were performed.METHODSAssays included the measurement of serum interleukin-6 and C-reactive-protein, as inflammatory markers; tryptophan, kynurenine, and their ratio as index of IDO activity; and neopterin, phenylalanine, tyrosine, and nitrite, as markers of GTP-CH1 activity. In addition, structured assessments of depressive symptomatology, fatigue, and general behavioral/neurovegetative symptoms were performed.As expected, age correlated significantly with concentrations of immune markers and neuropsychiatric symptoms. Increased inflammation was related to reduced tryptophan concentrations and increased kynurenine levels, suggestive of IDO-induced increased tryptophan catabolism. In addition, inflammation was associated with increases in neopterin and nitrite levels and in phenylalanine concentrations at the expense of tyrosine. Interestingly, increased tryptophan catabolism was associated with the depressive symptoms of lassitude, reduced motivation, anorexia, and pessimism. In contrast, variations in markers of GTP-CH1 activity correlated more with neurovegetative symptoms, including sleep disturbance, digestive symptoms, fatigue, sickness, and motor symptoms.RESULTSAs expected, age correlated significantly with concentrations of immune markers and neuropsychiatric symptoms. Increased inflammation was related to reduced tryptophan concentrations and increased kynurenine levels, suggestive of IDO-induced increased tryptophan catabolism. In addition, inflammation was associated with increases in neopterin and nitrite levels and in phenylalanine concentrations at the expense of tyrosine. Interestingly, increased tryptophan catabolism was associated with the depressive symptoms of lassitude, reduced motivation, anorexia, and pessimism. In contrast, variations in markers of GTP-CH1 activity correlated more with neurovegetative symptoms, including sleep disturbance, digestive symptoms, fatigue, sickness, and motor symptoms.These findings show that chronic low-grade inflammation in aging is associated with alterations in enzymatic pathways involved in monoamine metabolism and suggest that these alterations might participate in the pathophysiology of neuropsychiatric symptoms in elderly persons.CONCLUSIONSThese findings show that chronic low-grade inflammation in aging is associated with alterations in enzymatic pathways involved in monoamine metabolism and suggest that these alterations might participate in the pathophysiology of neuropsychiatric symptoms in elderly persons. Neuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of aging, plays a role. Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxygenase (IDO) and the guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis of monoamines. The present study assessed this possibility in 284 healthy elderly subjects drawn from the Three-City cohort. Assays included the measurement of serum interleukin-6 and C-reactive-protein, as inflammatory markers; tryptophan, kynurenine, and their ratio as index of IDO activity; and neopterin, phenylalanine, tyrosine, and nitrite, as markers of GTP-CH1 activity. In addition, structured assessments of depressive symptomatology, fatigue, and general behavioral/neurovegetative symptoms were performed. As expected, age correlated significantly with concentrations of immune markers and neuropsychiatric symptoms. Increased inflammation was related to reduced tryptophan concentrations and increased kynurenine levels, suggestive of IDO-induced increased tryptophan catabolism. In addition, inflammation was associated with increases in neopterin and nitrite levels and in phenylalanine concentrations at the expense of tyrosine. Interestingly, increased tryptophan catabolism was associated with the depressive symptoms of lassitude, reduced motivation, anorexia, and pessimism. In contrast, variations in markers of GTP-CH1 activity correlated more with neurovegetative symptoms, including sleep disturbance, digestive symptoms, fatigue, sickness, and motor symptoms. These findings show that chronic low-grade inflammation in aging is associated with alterations in enzymatic pathways involved in monoamine metabolism and suggest that these alterations might participate in the pathophysiology of neuropsychiatric symptoms in elderly persons. Background Neuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of aging, plays a role. Effects might rely on the influence of inflammation on the activity of two enzymatic pathways, the indoleamine-2,3-dioxygenase (IDO) and the guanosine-triphosphate-cyclohydrolase-1 (GTP-CH1) pathways, which are involved in the biosynthesis of monoamines. The present study assessed this possibility in 284 healthy elderly subjects drawn from the Three-City cohort. Methods Assays included the measurement of serum interleukin-6 and C-reactive-protein, as inflammatory markers; tryptophan, kynurenine, and their ratio as index of IDO activity; and neopterin, phenylalanine, tyrosine, and nitrite, as markers of GTP-CH1 activity. In addition, structured assessments of depressive symptomatology, fatigue, and general behavioral/neurovegetative symptoms were performed. Results As expected, age correlated significantly with concentrations of immune markers and neuropsychiatric symptoms. Increased inflammation was related to reduced tryptophan concentrations and increased kynurenine levels, suggestive of IDO-induced increased tryptophan catabolism. In addition, inflammation was associated with increases in neopterin and nitrite levels and in phenylalanine concentrations at the expense of tyrosine. Interestingly, increased tryptophan catabolism was associated with the depressive symptoms of lassitude, reduced motivation, anorexia, and pessimism. In contrast, variations in markers of GTP-CH1 activity correlated more with neurovegetative symptoms, including sleep disturbance, digestive symptoms, fatigue, sickness, and motor symptoms. Conclusions These findings show that chronic low-grade inflammation in aging is associated with alterations in enzymatic pathways involved in monoamine metabolism and suggest that these alterations might participate in the pathophysiology of neuropsychiatric symptoms in elderly persons. |
| Author | Capuron, Lucile Féart, Catherine Fuchs, Dietmar Barberger-Gateau, Pascale Aubert, Agnès Higueret, Denise Layé, Sophie Schroecksnadel, Sebastian |
| Author_xml | – sequence: 1 givenname: Lucile surname: Capuron fullname: Capuron, Lucile email: lucile.capuron@bordeaux.inra.fr organization: Laboratory of Psychoneuroimmunology, Nutrition and Genetics, INRA, Centre Hospitalier Universitaire of Bordeaux, Bordeaux, France – sequence: 2 givenname: Sebastian surname: Schroecksnadel fullname: Schroecksnadel, Sebastian organization: Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria – sequence: 3 givenname: Catherine surname: Féart fullname: Féart, Catherine organization: INSERM, University Victor Segalen Bordeaux 2, Centre Hospitalier Universitaire of Bordeaux, Bordeaux, France – sequence: 4 givenname: Agnès surname: Aubert fullname: Aubert, Agnès organization: Laboratory of Psychoneuroimmunology, Nutrition and Genetics, INRA, Centre Hospitalier Universitaire of Bordeaux, Bordeaux, France – sequence: 5 givenname: Denise surname: Higueret fullname: Higueret, Denise organization: Laboratory of Biochemistry, Centre Hospitalier Universitaire of Bordeaux, Bordeaux, France – sequence: 6 givenname: Pascale surname: Barberger-Gateau fullname: Barberger-Gateau, Pascale organization: INSERM, University Victor Segalen Bordeaux 2, Centre Hospitalier Universitaire of Bordeaux, Bordeaux, France – sequence: 7 givenname: Sophie surname: Layé fullname: Layé, Sophie organization: Laboratory of Psychoneuroimmunology, Nutrition and Genetics, INRA, Centre Hospitalier Universitaire of Bordeaux, Bordeaux, France – sequence: 8 givenname: Dietmar surname: Fuchs fullname: Fuchs, Dietmar organization: Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24343062$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21277567$$D View this record in MEDLINE/PubMed https://hal.inrae.fr/hal-02646644$$DView record in HAL |
| BookMark | eNqNUl1v0zAUjdAQ6wZ_YfILQjyk2I7rZAghqmpslcqHWN8tx7lRXRw72O6m_A1-MQ5tQdoD48m6V-cc33vuOctOrLOQZRcETwkm_M12WmvXh0FtphSPTTrFmD_JJqQqi5wyTE-yCU6tvKC0OM3OQtimsqSUPMtOKaFlOePlJPu52HhntUIrd59fe9kAWtrWyK6TUTuLtEVXpgFvBvQVfHA2oGVA8xCc0jJCg-513KC5ieBTsfZDH12_kRZJm8rBu6AtoE8QZe2MDt1b9M0ZGGU_w87vN0hCPk1wO3SJ3IXn2dNWmgAvDu95tv54tV7c5Ksv18vFfJWrGSMxV5xLXDNSVQUH3uCqJQ0FIGXdJke4kgWjmHNCiWSXmCjV8ktaU14zXlM6K86z13vZjTSi97qTfhBOanEzX4mxhylnnDN2RxL21R7be_djByGKTgcFxkgLbhdEVaY5WMVG1YsDcld30PwRPjqeAC8PABmUNK2XVunwF8cKVmBOE-7dHqeSh8FDK5SOv28SvdRGECzGIIitOAZBjEEQhIp09UTnD-jHHx4lftgTIVl_p8GLoDRYBY32oKJonH5c4v0DCWV0ypg032GAsHU7b9NhBREhEcTtGNMxpQTj5FJV_Fvgfyb4Bcs0-5M |
| CODEN | BIPCBF |
| CitedBy_id | crossref_primary_10_1016_j_bbi_2018_10_003 crossref_primary_10_1016_j_pnpbp_2017_04_035 crossref_primary_10_1016_j_bbi_2020_12_020 crossref_primary_10_2147_JIR_S338107 crossref_primary_10_1016_j_jhazmat_2025_137410 crossref_primary_10_1186_s12974_022_02473_3 crossref_primary_10_4161_2162402X_2014_992646 crossref_primary_10_3233_NUA_150049 crossref_primary_10_1016_j_bbi_2023_02_018 crossref_primary_10_1038_nrclinonc_2012_88 crossref_primary_10_1016_j_mad_2023_111890 crossref_primary_10_1016_j_bbi_2013_04_009 crossref_primary_10_1016_j_cbi_2018_07_023 crossref_primary_10_1111_bph_13926 crossref_primary_10_1007_s11011_021_00824_2 crossref_primary_10_1007_s11306_017_1221_z crossref_primary_10_1016_j_bbi_2024_08_048 crossref_primary_10_1002_jsfa_9414 crossref_primary_10_1080_15622975_2024_2346096 crossref_primary_10_1186_1471_244X_12_90 crossref_primary_10_1093_alcalc_agu011 crossref_primary_10_1017_S0007114514003821 crossref_primary_10_7717_peerj_3968 crossref_primary_10_2174_1871526523666230727093926 crossref_primary_10_3389_fevo_2022_1007052 crossref_primary_10_1007_s12640_022_00539_x crossref_primary_10_1016_j_ijbiomac_2021_05_172 crossref_primary_10_1038_s41598_019_39569_5 crossref_primary_10_3389_fpsyt_2020_00338 crossref_primary_10_1016_j_jad_2024_11_017 crossref_primary_10_3389_fpsyt_2017_00108 crossref_primary_10_3390_jcm10081744 crossref_primary_10_1038_npp_2013_115 crossref_primary_10_3389_fpsyt_2021_665682 crossref_primary_10_1038_s41398_023_02464_9 crossref_primary_10_1042_NS20220054 crossref_primary_10_1016_j_exger_2016_01_007 crossref_primary_10_1515_pterid_2016_0006 crossref_primary_10_1002_2327_6924_12129 crossref_primary_10_1007_s00702_021_02363_7 crossref_primary_10_1016_j_bbi_2012_10_010 crossref_primary_10_1016_j_mad_2021_111431 crossref_primary_10_3390_app11178155 crossref_primary_10_1016_j_scitotenv_2021_151689 crossref_primary_10_1002_jcsm_13045 crossref_primary_10_5114_reum_2017_68911 crossref_primary_10_1016_j_tins_2013_10_003 crossref_primary_10_1189_jlb_1HI0216_062RR crossref_primary_10_1016_j_biopha_2018_11_141 crossref_primary_10_3390_antiox10111795 crossref_primary_10_2174_1568026623666221223111309 crossref_primary_10_1021_acs_analchem_6b03421 crossref_primary_10_3390_ph12010009 crossref_primary_10_1051_ocl_2011_0412 crossref_primary_10_1111_acer_14920 crossref_primary_10_1177_11786469211039220 crossref_primary_10_2174_1871530321666210203212809 crossref_primary_10_2147_NDT_S429862 crossref_primary_10_3390_ijerph10072813 crossref_primary_10_1124_pharmrev_120_000043 crossref_primary_10_1016_S1875_5364_21_60029_8 crossref_primary_10_3390_ijms17122022 crossref_primary_10_1021_acssensors_4c01844 crossref_primary_10_1038_s41598_020_76219_7 crossref_primary_10_3389_fimmu_2017_01613 crossref_primary_10_1097_MCO_0b013e328359efd7 crossref_primary_10_4103_aja202434 crossref_primary_10_1016_j_pnpbp_2022_110633 crossref_primary_10_3389_fpsyt_2018_00250 crossref_primary_10_1016_j_psychres_2011_07_032 crossref_primary_10_1016_j_brainresbull_2017_12_001 crossref_primary_10_1038_npp_2016_66 crossref_primary_10_1016_j_molstruc_2018_05_105 crossref_primary_10_1007_s00702_019_02037_5 crossref_primary_10_1016_j_psyneuen_2023_106110 crossref_primary_10_1016_j_psyneuen_2019_03_028 crossref_primary_10_1155_2013_284543 crossref_primary_10_2460_ajvr_76_12_1014 crossref_primary_10_1016_j_bios_2023_115360 crossref_primary_10_1038_s41380_021_01265_0 crossref_primary_10_1016_j_envint_2019_04_003 crossref_primary_10_1080_00032719_2023_2270739 crossref_primary_10_1016_j_semcdb_2017_08_007 crossref_primary_10_1021_acs_jced_9b00562 crossref_primary_10_1007_s00604_023_05970_1 crossref_primary_10_1016_j_neuropharm_2020_107976 crossref_primary_10_3389_fimmu_2019_02565 crossref_primary_10_1007_s00394_014_0690_3 crossref_primary_10_1016_j_exger_2023_112088 crossref_primary_10_1093_jas_sky401 crossref_primary_10_2217_bmm_2017_0280 crossref_primary_10_1021_acs_jafc_8b04102 crossref_primary_10_3389_fneur_2024_1434139 crossref_primary_10_3389_fnmol_2017_00134 crossref_primary_10_3389_fpsyt_2017_00145 crossref_primary_10_3390_cells10102729 crossref_primary_10_1155_2018_8604718 crossref_primary_10_3390_ijms241914769 crossref_primary_10_1016_j_cellsig_2019_03_007 crossref_primary_10_1038_s41386_018_0038_4 crossref_primary_10_1016_j_psyneuen_2023_106334 crossref_primary_10_15430_JCP_2021_26_1_1 crossref_primary_10_1016_j_pnpbp_2012_10_006 crossref_primary_10_1097_gscm_0000000000000031 crossref_primary_10_1016_j_bbi_2020_11_035 crossref_primary_10_1016_j_neuroscience_2018_03_034 crossref_primary_10_1016_j_yfrne_2022_100993 crossref_primary_10_1016_j_bbi_2021_02_031 crossref_primary_10_1016_j_bbi_2012_11_011 crossref_primary_10_1016_j_neuroscience_2013_04_060 crossref_primary_10_1002_da_22084 crossref_primary_10_1016_j_bbi_2018_11_312 crossref_primary_10_3390_brainsci7110144 crossref_primary_10_1016_j_jnutbio_2018_05_002 crossref_primary_10_1186_s11556_024_00344_9 crossref_primary_10_1038_s41386_020_0607_1 crossref_primary_10_1097_SHK_0000000000002353 crossref_primary_10_1016_j_psychres_2015_05_068 crossref_primary_10_3390_nano12030421 crossref_primary_10_3389_fphar_2023_1131479 crossref_primary_10_1111_febs_15613 crossref_primary_10_1016_j_bbi_2012_11_002 crossref_primary_10_1016_j_mcn_2018_01_005 crossref_primary_10_1016_j_envint_2013_05_014 crossref_primary_10_1016_j_ica_2022_120928 crossref_primary_10_3390_brainsci10060322 crossref_primary_10_1002_adfm_202424018 crossref_primary_10_1016_j_mehy_2014_01_011 crossref_primary_10_3390_jcm8091368 crossref_primary_10_1371_journal_pone_0177763 crossref_primary_10_1016_j_jhep_2012_07_037 crossref_primary_10_1007_s12026_021_09238_9 crossref_primary_10_1007_s10522_025_10206_1 crossref_primary_10_1177_0091217419858277 crossref_primary_10_1080_15287394_2017_1286898 crossref_primary_10_2174_1574885517666220617124629 crossref_primary_10_1186_s12887_021_02602_6 crossref_primary_10_1016_j_heliyon_2023_e15010 crossref_primary_10_1097_PSY_0b013e318268de9f crossref_primary_10_1016_j_arr_2016_03_008 crossref_primary_10_1111_psyp_12833 crossref_primary_10_4137_IJTR_S36464 crossref_primary_10_1186_s12974_021_02330_9 crossref_primary_10_1016_j_neuint_2015_08_004 crossref_primary_10_1038_npp_2016_143 crossref_primary_10_1038_s41587_019_0321_x crossref_primary_10_1016_j_snb_2021_130842 crossref_primary_10_3233_JAD_200637 crossref_primary_10_1038_s41398_022_01835_y crossref_primary_10_1155_2014_783730 crossref_primary_10_1177_11786469231220781 crossref_primary_10_1038_npp_2011_205 crossref_primary_10_1016_j_jpba_2016_07_025 crossref_primary_10_1177_11786469231211184 crossref_primary_10_1186_s12974_018_1366_3 crossref_primary_10_1016_j_arr_2017_09_001 crossref_primary_10_1016_j_scitotenv_2022_153279 crossref_primary_10_1016_j_neuroscience_2014_10_028 crossref_primary_10_4137_IJTR_S10085 crossref_primary_10_1186_s12882_016_0387_3 crossref_primary_10_1016_j_bbi_2011_09_006 crossref_primary_10_1016_j_jamda_2017_06_021 crossref_primary_10_1051_ocl_2015064 crossref_primary_10_3390_diagnostics12092057 crossref_primary_10_1016_j_psyneuen_2018_02_030 crossref_primary_10_4014_jmb_2104_04038 crossref_primary_10_1016_j_jamda_2017_06_029 crossref_primary_10_1016_j_bbi_2012_08_008 crossref_primary_10_1007_s11357_020_00247_4 crossref_primary_10_1016_j_biopsych_2015_05_014 crossref_primary_10_3389_fimmu_2017_00021 crossref_primary_10_1093_braincomms_fcad231 crossref_primary_10_1093_rheumatology_kead068 crossref_primary_10_3390_nu15020256 crossref_primary_10_1097_MD_0000000000005066 crossref_primary_10_1371_journal_pone_0036956 crossref_primary_10_1016_j_bbi_2021_03_019 crossref_primary_10_1080_1061186X_2022_2120613 crossref_primary_10_1515_pteridines_2018_0008 crossref_primary_10_14336_AD_2017_0202 crossref_primary_10_31083_j_fbl2812356 crossref_primary_10_1007_s12035_018_1359_3 crossref_primary_10_1016_j_neubiorev_2016_02_017 crossref_primary_10_1038_npp_2016_123 crossref_primary_10_1016_j_jns_2013_03_007 crossref_primary_10_1210_jendso_bvae152 crossref_primary_10_1016_j_biopsych_2011_05_022 crossref_primary_10_1016_j_bbi_2014_06_200 crossref_primary_10_1016_j_psyneuen_2016_09_002 crossref_primary_10_1021_acsnano_1c05806 crossref_primary_10_1016_j_neubiorev_2014_02_004 crossref_primary_10_1515_pteridines_2019_0001 crossref_primary_10_1016_j_cmet_2015_07_005 crossref_primary_10_1038_s41598_018_29713_y crossref_primary_10_1016_j_scitotenv_2019_06_532 crossref_primary_10_4137_IJTR_S33385 crossref_primary_10_1016_j_bbi_2012_03_003 crossref_primary_10_1159_000509908 crossref_primary_10_1172_jci_insight_174007 crossref_primary_10_3389_fimmu_2019_02971 crossref_primary_10_1177_1178646920972657 crossref_primary_10_1002_ehf2_12755 crossref_primary_10_1016_j_exger_2023_112253 crossref_primary_10_1007_s00198_023_06803_w crossref_primary_10_1186_s11556_024_00336_9 crossref_primary_10_3389_fnins_2018_00499 crossref_primary_10_1111_cns_70150 crossref_primary_10_2174_1567205019666220920090919 crossref_primary_10_1016_j_jneuroim_2017_03_003 crossref_primary_10_3390_ijms18071595 crossref_primary_10_1093_rheumatology_kez413 crossref_primary_10_1016_j_jad_2018_04_007 crossref_primary_10_1016_j_scitotenv_2013_12_093 crossref_primary_10_1021_acs_jafc_3c08658 crossref_primary_10_1159_000496293 crossref_primary_10_1016_j_jagp_2019_05_011 crossref_primary_10_25259_JNRP_143_2024 crossref_primary_10_3390_nu12103019 crossref_primary_10_1007_s00198_014_2720_7 crossref_primary_10_1016_j_bbih_2019_100016 crossref_primary_10_1016_j_fct_2015_02_012 crossref_primary_10_3389_fmicb_2024_1428239 crossref_primary_10_1016_j_bbi_2011_11_001 crossref_primary_10_1371_journal_pone_0036861 crossref_primary_10_1016_j_npbr_2015_07_002 crossref_primary_10_1016_j_psychres_2018_03_045 crossref_primary_10_1007_s11357_015_9821_x crossref_primary_10_1016_j_tins_2018_09_008 crossref_primary_10_3390_ijerph191811622 crossref_primary_10_3390_metabo13050639 crossref_primary_10_1371_journal_pone_0024325 crossref_primary_10_1038_srep36833 crossref_primary_10_3389_fneur_2024_1386844 crossref_primary_10_1016_j_neuropharm_2016_02_030 crossref_primary_10_1007_s42242_024_00300_7 crossref_primary_10_1134_S1819712416010153 crossref_primary_10_1016_j_psyneuen_2015_06_001 crossref_primary_10_3389_fphys_2023_1117687 crossref_primary_10_1089_jir_2011_0093 crossref_primary_10_13109_zptm_2018_64_4_365 crossref_primary_10_1016_j_jns_2023_120819 crossref_primary_10_5114_reum_2015_53998 crossref_primary_10_1016_j_psyneuen_2015_07_609 crossref_primary_10_1111_febs_16558 crossref_primary_10_1007_s12035_018_1330_3 crossref_primary_10_1371_journal_ppat_1009243 crossref_primary_10_1016_j_ijcme_2015_11_002 crossref_primary_10_1016_j_psyneuen_2019_104371 crossref_primary_10_1016_j_micpath_2023_106487 crossref_primary_10_1093_jas_skz120 crossref_primary_10_1155_2022_5019752 crossref_primary_10_9758_cpn_2022_20_2_199 crossref_primary_10_18632_aging_203311 crossref_primary_10_1016_j_arr_2022_101573 crossref_primary_10_1016_j_bbi_2013_09_015 crossref_primary_10_1002_da_21945 crossref_primary_10_1007_s00508_020_01638_5 crossref_primary_10_1016_j_clnesp_2022_10_004 crossref_primary_10_1097_MCO_0000000000000237 crossref_primary_10_1155_2018_2980295 crossref_primary_10_3389_fendo_2014_00074 crossref_primary_10_1016_j_yfrne_2012_09_003 crossref_primary_10_1016_j_trim_2017_12_003 crossref_primary_10_1016_j_numecd_2014_11_004 crossref_primary_10_1007_s00018_017_2504_2 crossref_primary_10_1016_j_brainres_2014_06_032 crossref_primary_10_1371_journal_pone_0153617 |
| Cites_doi | 10.1089/jir.1986.6.389 10.1016/S0165-5728(98)00217-3 10.1093/clinchem/43.12.2424 10.1038/nm1490 10.1016/S0749-0690(03)00042-9 10.1002/j.2051-5545.2009.tb00234.x 10.1016/j.bbi.2009.11.004 10.1111/j.1365-3083.2005.01586.x 10.1111/j.1365-2249.2005.02746.x 10.1007/s00395-008-0714-3 10.1016/S0165-1781(01)00282-7 10.1002/eji.1830230950 10.1007/s00726-007-0625-x 10.1016/S0893-133X(01)00407-9 10.2174/1389200024605082 10.1159/000089002 10.1016/S0006-3223(03)00173-2 10.1016/S0891-5849(98)00293-7 10.1016/j.pnpbp.2010.01.002 10.1016/j.gtc.2009.06.009 10.1016/j.canlet.2008.07.002 10.1212/WNL.63.8_suppl_3.S2 10.1097/00002093-200000001-00008 10.1038/sj.mp.4000995 10.1016/S0140-6736(05)66665-2 10.1093/clinchem/40.2.288 10.1126/science.7901908 10.1017/S1092852900017260 10.1038/nrn2214 10.1016/j.iac.2009.02.007 10.4137/IJTR.S2097 10.1192/bjp.134.4.382 10.1016/j.biopsych.2004.02.009 10.1159/000072920 10.1111/j.1749-6632.2001.tb05836.x 10.1016/j.imlet.2005.03.008 10.1159/000096438 10.1503/cmaj.060792 10.1016/0022-3999(94)00125-O 10.1007/s11064-006-9233-5 10.1111/j.1600-0447.2006.00770.x 10.2174/138920008785821738 10.2174/1389200003339063 10.1080/07315724.1991.10718185 10.1038/mp.2009.116 10.1056/NEJM200103293441303 10.1111/j.1749-6632.1992.tb38712.x 10.3109/07357909509024923 10.1016/j.it.2005.11.006 10.1016/j.clinbiochem.2004.02.007 10.1159/000119064 10.1017/S0007114509990493 10.1111/j.1749-6632.2009.05356.x 10.1016/j.mad.2006.11.016 10.1038/nm954 10.1111/j.1749-6632.2000.tb06651.x 10.1096/fj.05-3776fje |
| ContentType | Journal Article |
| Copyright | 2011 Society of Biological Psychiatry Society of Biological Psychiatry 2015 INIST-CNRS Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. Distributed under a Creative Commons Attribution 4.0 International License |
| Copyright_xml | – notice: 2011 Society of Biological Psychiatry – notice: Society of Biological Psychiatry – notice: 2015 INIST-CNRS – notice: Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. – notice: Distributed under a Creative Commons Attribution 4.0 International License |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 1XC |
| DOI | 10.1016/j.biopsych.2010.12.006 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Hyper Article en Ligne (HAL) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Biology |
| EISSN | 1873-2402 |
| EndPage | 182 |
| ExternalDocumentID | oai_HAL_hal_02646644v1 21277567 24343062 10_1016_j_biopsych_2010_12_006 S0006322310012783 1_s2_0_S0006322310012783 |
| Genre | Research Support, Non-U.S. Gov't Multicenter Study Journal Article |
| GroupedDBID | --- --K --M -DZ .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABCQX ABDPE ABFNM ABFRF ABIVO ABJNI ABLJU ABMAC ABMZM ABWVN ABXDB ACDAQ ACGFO ACIEU ACIUM ACNCT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGCQF AGHFR AGQPQ AGUBO AGWIK AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEG HMK HMO HMQ HVGLF HZ~ H~9 IHE J1W KOM L7B M29 M2V M39 M41 MO0 MOBAO N9A O-L O9- OAUVE OH0 OU- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SNS SPCBC SSH SSN SSZ T5K UAP UNMZH UPT UV1 WH7 WUQ XJT XOL Z5R ZCA ZGI ZKB ZXP ~G- AACTN AFCTW AFKWA AJOXV AMFUW PKN RIG AADPK AAIAV ABLVK ABYKQ AJBFU EFLBG G8K LCYCR ZA5 AAYXX AGRNS CITATION 08R ABPIF ABPTK IQODW CGR CUY CVF ECM EIF NPM 7X8 1XC |
| ID | FETCH-LOGICAL-c541t-c66a0b418836e6d08f1d2ee17bf2016ca342066121a4901ccf692b26b46b2253 |
| IEDL.DBID | .~1 |
| ISSN | 0006-3223 1873-2402 |
| IngestDate | Fri May 09 12:22:27 EDT 2025 Fri Jul 11 02:32:27 EDT 2025 Thu Apr 03 07:01:17 EDT 2025 Sun Oct 22 16:06:10 EDT 2023 Tue Jul 01 03:38:04 EDT 2025 Thu Apr 24 23:10:09 EDT 2025 Fri Feb 23 02:26:53 EST 2024 Sun Feb 23 10:19:38 EST 2025 Tue Aug 26 16:31:51 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Aging enzymatic pathways tyrosine neuropsychiatric symptoms inflammation tryptophan Human Tyrosine Senescence Neuropsychiatry Tryptophan Inflammation Metabolism Symptomatology Chronic Aminoacid Mental disorder Elderly TRYPTOPHAN AGING ENZYMATIC PATHWAYS TYROSINE NEUROPSYCHIATRIC SYMPTOMS INFLAMMATION |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c541t-c66a0b418836e6d08f1d2ee17bf2016ca342066121a4901ccf692b26b46b2253 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-3843-1012 0000-0002-2060-5918 |
| PMID | 21277567 |
| PQID | 874184845 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | hal_primary_oai_HAL_hal_02646644v1 proquest_miscellaneous_874184845 pubmed_primary_21277567 pascalfrancis_primary_24343062 crossref_citationtrail_10_1016_j_biopsych_2010_12_006 crossref_primary_10_1016_j_biopsych_2010_12_006 elsevier_sciencedirect_doi_10_1016_j_biopsych_2010_12_006 elsevier_clinicalkeyesjournals_1_s2_0_S0006322310012783 elsevier_clinicalkey_doi_10_1016_j_biopsych_2010_12_006 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2011-07-15 |
| PublicationDateYYYYMMDD | 2011-07-15 |
| PublicationDate_xml | – month: 07 year: 2011 text: 2011-07-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | New York, NY |
| PublicationPlace_xml | – name: New York, NY – name: United States |
| PublicationTitle | Biological psychiatry (1969) |
| PublicationTitleAlternate | Biol Psychiatry |
| PublicationYear | 2011 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Winkler, Schroecksnadel, Schennach, Fuchs (bib61) 2007; 142 Fagiolo, Cossarizza, Santacaterina, Ortolani, Monti, Paganelli, Franceschi (bib10) 1992; 663 Floyd (bib13) 1999; 26 Widner, Ledochowski, Fuchs (bib27) 2000; 1 Valentine, Meyers, Talpaz (bib44) 1995; 13 Musselman, Lawson, Gumnick, Manatunga, Penna, Goodkin (bib20) 2001; 344 Hashimoto, Mizutani, Ohta, Nakazawa, Nagatsu (bib30) 1994; 29 (bib38) 2003; 22 Raitala, Pertovaara, Karjalainen, Oja, Hurme (bib45) 2005; 61 Fagiolo, Cossarizza, Scala, Fanales-Belasio, Ortolani, Cozzi (bib9) 1993; 23 Richardson, Read, Reilly, Clelland, Clelland (bib33) 2007; 32 Godbout, Chen, Abraham, Richwine, Berg, Kelley, Johnson (bib8) 2005; 19 Schroecksnadel, Winkler, Wirleitner, Schennach, Fuchs (bib62) 2005; 140 Raison, Capuron, Miller (bib6) 2006; 27 Cosby, Partovi, Crawford, Patel, Reiter, Martyr (bib56) 2003; 9 Celik, Erdem, Cayci, Ozdemir, Ozgur Akgul, Kurt (bib34) 2010; 34 Ploder, Neurauter, Spittler, Schroecksnadel, Roth, Fuchs (bib28) 2008; 35 Oxenkrug (bib46) 2010; 1199 Calati, De Ronchi, Bellini, Serretti (bib52) 2010 Smets, Garssen, Bonke, De Haes (bib43) 1995; 39 Murr, Widner, Wirleitner, Fuchs (bib25) 2002; 3 Visvanathan, Chapman (bib50) 2009; 38 Capuron, Miller (bib7) 2004; 56 Neurauter, Schrocksnadel, Scholl-Burgi, Sperner-Unterweger, Schubert, Ledochowski, Fuchs (bib26) 2008; 9 Coyle, Puttfarcken (bib16) 1993; 262 Tegeder, Costigan, Griffin, Abele, Belfer, Schmidt (bib55) 2006; 12 Godbout, Johnson (bib5) 2009; 29 Ader (bib18) 2007 Owens, Nemeroff (bib51) 1994; 40 Djernes (bib1) 2006; 113 Capuron, Neurauter, Musselman, Lawson, Nemeroff, Fuchs, Miller (bib36) 2003; 54 Calabrese, Mancuso, Calvani, Rizzarelli, Butterfield, Stella (bib58) 2007; 8 Byrne, Lehmann, Kirschbaum, Borden, Lee, Brown (bib22) 1986; 6 Chen, Guillemin (bib23) 2009; 2 Raison, Dantzer, Kelley, Lawson, Woolwine, Vogt (bib37) 2010; 15 Wolkove, Elkholy, Baltzan, Palayew (bib49) 2007; 176 Montgomery, Asberg (bib41) 1979; 134 Ye, Johnson (bib14) 1999; 93 Hoekstra, van den Broek, Fekkes, Bruijn, Mulder, Pepplinkhuizen (bib31) 2001; 103 Alexopoulos, Kelly (bib2) 2009; 8 Widner, Werner, Schennach, Wachter, Fuchs (bib24) 1997; 43 Sheehan, Lecrubier, Sheehan, Amorim, Janavs, Weiller (bib42) 1998; 59 Lauer, Heiss, Balzer, Kehmeier, Mangold, Leyendecker (bib57) 2008; 103 Akiyama, Arai, Kondo, Tanno, Haga, Ikeda (bib15) 2000; 14 Mehta, Morgan, Sethi (bib53) 2008; 13 Richardson, Read, Taylor Clelland, Reilly, Chao, Guynn (bib32) 2005; 52 Capuron, Moranis, Combe, Cousson-Gelie, Fuchs, De Smedt-Peyrusse (bib21) 2009; 102 Pall, Satterlee (bib59) 2001; 933 Rye (bib54) 2004; 63 Hybels, Blazer (bib4) 2003; 19 Sarwar, Botting, Collins (bib48) 1991; 10 Dantzer, Wollman, Yirmiya (bib17) 1999 Capuron, Gumnick, Musselman, Lawson, Reemsnyder, Nemeroff, Miller (bib19) 2002; 26 Neurauter, Grahmann, Klieber, Zeimet, Ledochowski, Sperner-Unterweger, Fuchs (bib40) 2008; 272 Wirleitner, Schroecksnadel, Winkler, Schennach, Fuchs (bib60) 2005; 100 Capuron, Ravaud, Neveu, Miller, Maes, Dantzer (bib35) 2002; 7 Franceschi, Capri, Monti, Giunta, Olivieri, Sevini (bib12) 2007; 128 Zangerle, Kurz, Neurauter, Kitchen, Sarcletti, Fuchs (bib29) 2010; 24 Griess (bib39) 1879; 12 Franceschi, Bonafe, Valensin, Olivieri, De Luca, Ottaviani, De Benedictis (bib11) 2000; 908 Frick, Schroecksnadel, Neurauter, Leblhuber, Fuchs (bib47) 2004; 37 Alexopoulos (bib3) 2005; 365 Montgomery (10.1016/j.biopsych.2010.12.006_bib41) 1979; 134 Fagiolo (10.1016/j.biopsych.2010.12.006_bib9) 1993; 23 Frick (10.1016/j.biopsych.2010.12.006_bib47) 2004; 37 Hybels (10.1016/j.biopsych.2010.12.006_bib4) 2003; 19 Capuron (10.1016/j.biopsych.2010.12.006_bib36) 2003; 54 Raison (10.1016/j.biopsych.2010.12.006_bib37) 2010; 15 Wirleitner (10.1016/j.biopsych.2010.12.006_bib60) 2005; 100 Schroecksnadel (10.1016/j.biopsych.2010.12.006_bib62) 2005; 140 Djernes (10.1016/j.biopsych.2010.12.006_bib1) 2006; 113 Valentine (10.1016/j.biopsych.2010.12.006_bib44) 1995; 13 Cosby (10.1016/j.biopsych.2010.12.006_bib56) 2003; 9 Owens (10.1016/j.biopsych.2010.12.006_bib51) 1994; 40 Calati (10.1016/j.biopsych.2010.12.006_bib52) 2010 (10.1016/j.biopsych.2010.12.006_bib38) 2003; 22 Smets (10.1016/j.biopsych.2010.12.006_bib43) 1995; 39 Neurauter (10.1016/j.biopsych.2010.12.006_bib40) 2008; 272 Mehta (10.1016/j.biopsych.2010.12.006_bib53) 2008; 13 Capuron (10.1016/j.biopsych.2010.12.006_bib7) 2004; 56 Lauer (10.1016/j.biopsych.2010.12.006_bib57) 2008; 103 Franceschi (10.1016/j.biopsych.2010.12.006_bib11) 2000; 908 Floyd (10.1016/j.biopsych.2010.12.006_bib13) 1999; 26 Raitala (10.1016/j.biopsych.2010.12.006_bib45) 2005; 61 Tegeder (10.1016/j.biopsych.2010.12.006_bib55) 2006; 12 Chen (10.1016/j.biopsych.2010.12.006_bib23) 2009; 2 Godbout (10.1016/j.biopsych.2010.12.006_bib8) 2005; 19 Dantzer (10.1016/j.biopsych.2010.12.006_bib17) 1999 Sarwar (10.1016/j.biopsych.2010.12.006_bib48) 1991; 10 Coyle (10.1016/j.biopsych.2010.12.006_bib16) 1993; 262 Ye (10.1016/j.biopsych.2010.12.006_bib14) 1999; 93 Murr (10.1016/j.biopsych.2010.12.006_bib25) 2002; 3 Widner (10.1016/j.biopsych.2010.12.006_bib27) 2000; 1 Ader (10.1016/j.biopsych.2010.12.006_bib18) 2007 Fagiolo (10.1016/j.biopsych.2010.12.006_bib10) 1992; 663 Hoekstra (10.1016/j.biopsych.2010.12.006_bib31) 2001; 103 Godbout (10.1016/j.biopsych.2010.12.006_bib5) 2009; 29 Wolkove (10.1016/j.biopsych.2010.12.006_bib49) 2007; 176 Alexopoulos (10.1016/j.biopsych.2010.12.006_bib3) 2005; 365 Akiyama (10.1016/j.biopsych.2010.12.006_bib15) 2000; 14 Capuron (10.1016/j.biopsych.2010.12.006_bib21) 2009; 102 Neurauter (10.1016/j.biopsych.2010.12.006_bib26) 2008; 9 Franceschi (10.1016/j.biopsych.2010.12.006_bib12) 2007; 128 Oxenkrug (10.1016/j.biopsych.2010.12.006_bib46) 2010; 1199 Byrne (10.1016/j.biopsych.2010.12.006_bib22) 1986; 6 Pall (10.1016/j.biopsych.2010.12.006_bib59) 2001; 933 Richardson (10.1016/j.biopsych.2010.12.006_bib32) 2005; 52 Rye (10.1016/j.biopsych.2010.12.006_bib54) 2004; 63 Hashimoto (10.1016/j.biopsych.2010.12.006_bib30) 1994; 29 Richardson (10.1016/j.biopsych.2010.12.006_bib33) 2007; 32 Winkler (10.1016/j.biopsych.2010.12.006_bib61) 2007; 142 Capuron (10.1016/j.biopsych.2010.12.006_bib19) 2002; 26 Alexopoulos (10.1016/j.biopsych.2010.12.006_bib2) 2009; 8 Celik (10.1016/j.biopsych.2010.12.006_bib34) 2010; 34 Ploder (10.1016/j.biopsych.2010.12.006_bib28) 2008; 35 Widner (10.1016/j.biopsych.2010.12.006_bib24) 1997; 43 Griess (10.1016/j.biopsych.2010.12.006_bib39) 1879; 12 Musselman (10.1016/j.biopsych.2010.12.006_bib20) 2001; 344 Capuron (10.1016/j.biopsych.2010.12.006_bib35) 2002; 7 Visvanathan (10.1016/j.biopsych.2010.12.006_bib50) 2009; 38 Zangerle (10.1016/j.biopsych.2010.12.006_bib29) 2010; 24 Sheehan (10.1016/j.biopsych.2010.12.006_bib42) 1998; 59 Raison (10.1016/j.biopsych.2010.12.006_bib6) 2006; 27 Calabrese (10.1016/j.biopsych.2010.12.006_bib58) 2007; 8 21708303 - Biol Psychiatry. 2011 Jul 15;70(2):111-2 |
| References_xml | – volume: 103 start-page: 291 year: 2008 end-page: 297 ident: bib57 article-title: Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise publication-title: Basic Res Cardiol – volume: 7 start-page: 468 year: 2002 end-page: 473 ident: bib35 article-title: Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy publication-title: Mol Psychiatry – volume: 26 start-page: 643 year: 2002 end-page: 652 ident: bib19 article-title: Neurobehavioral effects of interferon-α in cancer patients: Phenomenology and paroxetine responsiveness of symptom dimensions publication-title: Neuropsychopharmacology – volume: 2 start-page: 1 year: 2009 end-page: 19 ident: bib23 article-title: Kynurenine pathway metabolites in humans: Disease and healthy states publication-title: Int J Tryptophan Res – volume: 19 start-page: 1329 year: 2005 end-page: 1331 ident: bib8 article-title: Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system publication-title: FASEB J – volume: 262 start-page: 689 year: 1993 end-page: 695 ident: bib16 article-title: Oxidative stress, glutamate, and neurodegenerative disorders publication-title: Science – volume: 365 start-page: 1961 year: 2005 end-page: 1970 ident: bib3 article-title: Depression in the elderly publication-title: Lancet – volume: 6 start-page: 389 year: 1986 end-page: 396 ident: bib22 article-title: Induction of tryptophan degradation in vitro and in vivo: A gamma-interferon-stimulated activity publication-title: J Interferon Res – volume: 1199 start-page: 1 year: 2010 end-page: 14 ident: bib46 article-title: Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism publication-title: Ann N Y Acad Sci – volume: 663 start-page: 490 year: 1992 end-page: 493 ident: bib10 article-title: Increased cytokine production by peripheral blood mononuclear cells from healthy elderly people publication-title: Ann N Y Acad Sci – volume: 26 start-page: 1346 year: 1999 end-page: 1355 ident: bib13 article-title: Neuroinflammatory processes are important in neurodegenerative diseases: An hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development publication-title: Free Radic Biol Med – volume: 24 start-page: 403 year: 2010 end-page: 408 ident: bib29 article-title: Increased blood phenylalanine to tyrosine ratio in HIV-1 infection and correction following effective antiretroviral therapy publication-title: Brain Behav Immun – volume: 128 start-page: 92 year: 2007 end-page: 105 ident: bib12 article-title: Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans publication-title: Mech Ageing Dev – volume: 12 start-page: 426 year: 1879 end-page: 428 ident: bib39 article-title: Bemerkungen zu der Abhandlung der HH publication-title: Chemistry – volume: 35 start-page: 303 year: 2008 end-page: 307 ident: bib28 article-title: Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations publication-title: Amino Acids – volume: 52 start-page: 190 year: 2005 end-page: 201 ident: bib32 article-title: Evidence for a tetrahydrobiopterin deficit in schizophrenia publication-title: Neuropsychobiology – volume: 344 start-page: 961 year: 2001 end-page: 966 ident: bib20 article-title: Paroxetine for the prevention of depression induced by high-dose interferon alfa publication-title: N Engl J Med – volume: 102 start-page: 1390 year: 2009 end-page: 1394 ident: bib21 article-title: Vitamin E status and quality of life in the elderly: Influence of inflammatory processes publication-title: Br J Nutr – volume: 61 start-page: 387 year: 2005 end-page: 390 ident: bib45 article-title: Association of interferon-gamma +874(T/A) single nucleotide polymorphism with the rate of tryptophan catabolism in healthy individuals publication-title: Scand J Immunol – volume: 176 start-page: 1299 year: 2007 end-page: 1304 ident: bib49 article-title: Sleep and aging: 1 publication-title: CMAJ – volume: 27 start-page: 24 year: 2006 end-page: 31 ident: bib6 article-title: Cytokines sing the blues: Inflammation and the pathogenesis of depression publication-title: Trends Immunol – volume: 59 start-page: 22 year: 1998 end-page: 33 ident: bib42 article-title: The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 publication-title: J Clin Psychiatry – year: 1999 ident: bib17 article-title: Cytokines, Stress and Depression – volume: 12 start-page: 1269 year: 2006 end-page: 1277 ident: bib55 article-title: GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence publication-title: Nat Med – volume: 9 start-page: 622 year: 2008 end-page: 627 ident: bib26 article-title: Chronic immune stimulation correlates with reduced phenylalanine turnover publication-title: Curr Drug Metab – volume: 908 start-page: 244 year: 2000 end-page: 254 ident: bib11 article-title: Inflamm-aging publication-title: Ann N Y Acad Sci – volume: 134 start-page: 382 year: 1979 end-page: 389 ident: bib41 article-title: A new depression scale designed to be sensitive to change publication-title: Br J Psychiatry – volume: 40 start-page: 288 year: 1994 end-page: 295 ident: bib51 article-title: Role of serotonin in the pathophysiology of depression: Focus on the serotonin transporter publication-title: Clin Chem – volume: 34 start-page: 372 year: 2010 end-page: 375 ident: bib34 article-title: The association between serum levels of neopterin and number of depressive episodes of major depression publication-title: Prog Neuropsychopharmacol Biol Psychiatry – volume: 29 start-page: 57 year: 1994 end-page: 60 ident: bib30 article-title: Changes in plasma tetrahydrobiopterin levels of depressives in depressive and remission phases: Reconfirmed by measurement with an internal standard publication-title: Neuropsychobiology – volume: 142 start-page: 127 year: 2007 end-page: 132 ident: bib61 article-title: Vitamin C and E suppress mitogen-stimulated peripheral blood mononuclear cells in vitro publication-title: Int Arch Allergy Immunol – volume: 43 start-page: 2424 year: 1997 end-page: 2426 ident: bib24 article-title: Simultaneous measurement of serum tryptophan and kynurenine by HPLC publication-title: Clin Chem – volume: 13 start-page: 6 year: 2008 end-page: 11 ident: bib53 article-title: Sleep disorders associated with Parkinson's disease: Role of dopamine, epidemiology, and clinical scales of assessment publication-title: CNS Spectr – volume: 140 start-page: 41 year: 2005 end-page: 45 ident: bib62 article-title: Aspirin down-regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro publication-title: Clin Exp Immunol – volume: 29 start-page: 321 year: 2009 end-page: 337 ident: bib5 article-title: Age and neuroinflammation: A lifetime of psychoneuroimmune consequences publication-title: Immunol Allergy Clin North Am – volume: 23 start-page: 2375 year: 1993 end-page: 2378 ident: bib9 article-title: Increased cytokine production in mononuclear cells of healthy elderly people publication-title: Eur J Immunol – volume: 56 start-page: 819 year: 2004 end-page: 824 ident: bib7 article-title: Cytokines and psychopathology: Lessons from interferon-alpha publication-title: Biol Psychiatry – volume: 10 start-page: 668 year: 1991 end-page: 674 ident: bib48 article-title: A comparison of fasting serum amino acid profiles of young and elderly subjects publication-title: J Am Coll Nutr – volume: 39 start-page: 315 year: 1995 end-page: 325 ident: bib43 article-title: The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue publication-title: J Psychosom Res – volume: 3 start-page: 175 year: 2002 end-page: 187 ident: bib25 article-title: Neopterin as a marker for immune system activation publication-title: Curr Drug Metab – volume: 8 start-page: 140 year: 2009 end-page: 149 ident: bib2 article-title: Research advances in geriatric depression publication-title: World Psychiatry – volume: 32 start-page: 107 year: 2007 end-page: 113 ident: bib33 article-title: Analysis of plasma biopterin levels in psychiatric disorders suggests a common BH4 deficit in schizophrenia and schizoaffective disorder publication-title: Neurochem Res – volume: 22 start-page: 316 year: 2003 end-page: 325 ident: bib38 article-title: Vascular factors and risk of dementia: Design of the Three-City Study and baseline characteristics of the study population publication-title: Neuroepidemiology – volume: 19 start-page: 663 year: 2003 end-page: 696 ident: bib4 article-title: Epidemiology of late-life mental disorders publication-title: Clin Geriatr Med – volume: 14 start-page: S47 year: 2000 end-page: S53 ident: bib15 article-title: Cell mediators of inflammation in the Alzheimer disease brain publication-title: Alzheimer Dis Assoc Disord – volume: 54 start-page: 906 year: 2003 end-page: 914 ident: bib36 article-title: Interferon-alpha-induced changes in tryptophan metabolism: Relationship to depression and paroxetine treatment publication-title: Biol Psychiatry – volume: 272 start-page: 141 year: 2008 end-page: 147 ident: bib40 article-title: Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8 publication-title: Cancer Lett – volume: 113 start-page: 372 year: 2006 end-page: 387 ident: bib1 article-title: Prevalence and predictors of depression in populations of elderly: A review publication-title: Acta Psychiatr Scand – volume: 1 start-page: 193 year: 2000 end-page: 204 ident: bib27 article-title: Interferon-gamma-induced tryptophan degradation: Neuropsychiatric and immunological consequences publication-title: Curr Drug Metab – volume: 8 start-page: 766 year: 2007 end-page: 775 ident: bib58 article-title: Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity publication-title: Nat Rev Neurosci – volume: 63 start-page: S2 year: 2004 end-page: S7 ident: bib54 article-title: The two faces of Eve: Dopamine's modulation of wakefulness and sleep publication-title: Neurology – volume: 933 start-page: 323 year: 2001 end-page: 329 ident: bib59 article-title: Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder publication-title: Ann N Y Acad Sci – volume: 37 start-page: 684 year: 2004 end-page: 687 ident: bib47 article-title: Increasing production of homocysteine and neopterin and degradation of tryptophan with older age publication-title: Clin Biochem – volume: 100 start-page: 159 year: 2005 end-page: 163 ident: bib60 article-title: Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro publication-title: Immunol Lett – volume: 13 start-page: 561 year: 1995 end-page: 566 ident: bib44 article-title: Treatment of neurotoxic side effects of interferon-alpha with naltrexone publication-title: Cancer Invest – volume: 15 start-page: 393 year: 2010 end-page: 403 ident: bib37 article-title: CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: Relationship to CNS immune responses and depression publication-title: Mol Psychiatry – volume: 93 start-page: 139 year: 1999 end-page: 148 ident: bib14 article-title: Increased interleukin-6 expression by microglia from brain of aged mice publication-title: J Neuroimmunol – volume: 103 start-page: 115 year: 2001 end-page: 123 ident: bib31 article-title: Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression publication-title: Psychiatry Res – year: 2010 ident: bib52 article-title: The 5-HTTLPR polymorphism and eating disorders: A meta-analysis publication-title: Int J Eat Disord – volume: 38 start-page: 393 year: 2009 end-page: 409 ident: bib50 article-title: Undernutrition and anorexia in the older person publication-title: Gastroenterol Clin North Am – year: 2007 ident: bib18 article-title: Psychoneuroimmunology – volume: 9 start-page: 1498 year: 2003 end-page: 1505 ident: bib56 article-title: Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation publication-title: Nat Med – volume: 6 start-page: 389 year: 1986 ident: 10.1016/j.biopsych.2010.12.006_bib22 article-title: Induction of tryptophan degradation in vitro and in vivo: A gamma-interferon-stimulated activity publication-title: J Interferon Res doi: 10.1089/jir.1986.6.389 – volume: 93 start-page: 139 year: 1999 ident: 10.1016/j.biopsych.2010.12.006_bib14 article-title: Increased interleukin-6 expression by microglia from brain of aged mice publication-title: J Neuroimmunol doi: 10.1016/S0165-5728(98)00217-3 – volume: 43 start-page: 2424 year: 1997 ident: 10.1016/j.biopsych.2010.12.006_bib24 article-title: Simultaneous measurement of serum tryptophan and kynurenine by HPLC publication-title: Clin Chem doi: 10.1093/clinchem/43.12.2424 – volume: 12 start-page: 1269 year: 2006 ident: 10.1016/j.biopsych.2010.12.006_bib55 article-title: GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence publication-title: Nat Med doi: 10.1038/nm1490 – volume: 19 start-page: 663 year: 2003 ident: 10.1016/j.biopsych.2010.12.006_bib4 article-title: Epidemiology of late-life mental disorders publication-title: Clin Geriatr Med doi: 10.1016/S0749-0690(03)00042-9 – volume: 8 start-page: 140 year: 2009 ident: 10.1016/j.biopsych.2010.12.006_bib2 article-title: Research advances in geriatric depression publication-title: World Psychiatry doi: 10.1002/j.2051-5545.2009.tb00234.x – volume: 24 start-page: 403 year: 2010 ident: 10.1016/j.biopsych.2010.12.006_bib29 article-title: Increased blood phenylalanine to tyrosine ratio in HIV-1 infection and correction following effective antiretroviral therapy publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2009.11.004 – volume: 61 start-page: 387 year: 2005 ident: 10.1016/j.biopsych.2010.12.006_bib45 article-title: Association of interferon-gamma +874(T/A) single nucleotide polymorphism with the rate of tryptophan catabolism in healthy individuals publication-title: Scand J Immunol doi: 10.1111/j.1365-3083.2005.01586.x – volume: 140 start-page: 41 year: 2005 ident: 10.1016/j.biopsych.2010.12.006_bib62 article-title: Aspirin down-regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2005.02746.x – year: 1999 ident: 10.1016/j.biopsych.2010.12.006_bib17 – volume: 103 start-page: 291 year: 2008 ident: 10.1016/j.biopsych.2010.12.006_bib57 article-title: Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise publication-title: Basic Res Cardiol doi: 10.1007/s00395-008-0714-3 – volume: 103 start-page: 115 year: 2001 ident: 10.1016/j.biopsych.2010.12.006_bib31 article-title: Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression publication-title: Psychiatry Res doi: 10.1016/S0165-1781(01)00282-7 – volume: 23 start-page: 2375 year: 1993 ident: 10.1016/j.biopsych.2010.12.006_bib9 article-title: Increased cytokine production in mononuclear cells of healthy elderly people publication-title: Eur J Immunol doi: 10.1002/eji.1830230950 – volume: 35 start-page: 303 year: 2008 ident: 10.1016/j.biopsych.2010.12.006_bib28 article-title: Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations publication-title: Amino Acids doi: 10.1007/s00726-007-0625-x – volume: 26 start-page: 643 year: 2002 ident: 10.1016/j.biopsych.2010.12.006_bib19 article-title: Neurobehavioral effects of interferon-α in cancer patients: Phenomenology and paroxetine responsiveness of symptom dimensions publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(01)00407-9 – volume: 3 start-page: 175 year: 2002 ident: 10.1016/j.biopsych.2010.12.006_bib25 article-title: Neopterin as a marker for immune system activation publication-title: Curr Drug Metab doi: 10.2174/1389200024605082 – volume: 52 start-page: 190 year: 2005 ident: 10.1016/j.biopsych.2010.12.006_bib32 article-title: Evidence for a tetrahydrobiopterin deficit in schizophrenia publication-title: Neuropsychobiology doi: 10.1159/000089002 – volume: 54 start-page: 906 year: 2003 ident: 10.1016/j.biopsych.2010.12.006_bib36 article-title: Interferon-alpha-induced changes in tryptophan metabolism: Relationship to depression and paroxetine treatment publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(03)00173-2 – volume: 26 start-page: 1346 year: 1999 ident: 10.1016/j.biopsych.2010.12.006_bib13 article-title: Neuroinflammatory processes are important in neurodegenerative diseases: An hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(98)00293-7 – volume: 34 start-page: 372 year: 2010 ident: 10.1016/j.biopsych.2010.12.006_bib34 article-title: The association between serum levels of neopterin and number of depressive episodes of major depression publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2010.01.002 – volume: 38 start-page: 393 year: 2009 ident: 10.1016/j.biopsych.2010.12.006_bib50 article-title: Undernutrition and anorexia in the older person publication-title: Gastroenterol Clin North Am doi: 10.1016/j.gtc.2009.06.009 – volume: 272 start-page: 141 year: 2008 ident: 10.1016/j.biopsych.2010.12.006_bib40 article-title: Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8 publication-title: Cancer Lett doi: 10.1016/j.canlet.2008.07.002 – volume: 63 start-page: S2 issue: suppl 3 year: 2004 ident: 10.1016/j.biopsych.2010.12.006_bib54 article-title: The two faces of Eve: Dopamine's modulation of wakefulness and sleep publication-title: Neurology doi: 10.1212/WNL.63.8_suppl_3.S2 – volume: 14 start-page: S47 issue: suppl 1 year: 2000 ident: 10.1016/j.biopsych.2010.12.006_bib15 article-title: Cell mediators of inflammation in the Alzheimer disease brain publication-title: Alzheimer Dis Assoc Disord doi: 10.1097/00002093-200000001-00008 – volume: 7 start-page: 468 year: 2002 ident: 10.1016/j.biopsych.2010.12.006_bib35 article-title: Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4000995 – volume: 365 start-page: 1961 year: 2005 ident: 10.1016/j.biopsych.2010.12.006_bib3 article-title: Depression in the elderly publication-title: Lancet doi: 10.1016/S0140-6736(05)66665-2 – volume: 40 start-page: 288 year: 1994 ident: 10.1016/j.biopsych.2010.12.006_bib51 article-title: Role of serotonin in the pathophysiology of depression: Focus on the serotonin transporter publication-title: Clin Chem doi: 10.1093/clinchem/40.2.288 – volume: 262 start-page: 689 year: 1993 ident: 10.1016/j.biopsych.2010.12.006_bib16 article-title: Oxidative stress, glutamate, and neurodegenerative disorders publication-title: Science doi: 10.1126/science.7901908 – volume: 12 start-page: 426 year: 1879 ident: 10.1016/j.biopsych.2010.12.006_bib39 article-title: Bemerkungen zu der Abhandlung der HH publication-title: Chemistry – volume: 13 start-page: 6 issue: suppl 4 year: 2008 ident: 10.1016/j.biopsych.2010.12.006_bib53 article-title: Sleep disorders associated with Parkinson's disease: Role of dopamine, epidemiology, and clinical scales of assessment publication-title: CNS Spectr doi: 10.1017/S1092852900017260 – volume: 8 start-page: 766 year: 2007 ident: 10.1016/j.biopsych.2010.12.006_bib58 article-title: Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity publication-title: Nat Rev Neurosci doi: 10.1038/nrn2214 – volume: 29 start-page: 321 year: 2009 ident: 10.1016/j.biopsych.2010.12.006_bib5 article-title: Age and neuroinflammation: A lifetime of psychoneuroimmune consequences publication-title: Immunol Allergy Clin North Am doi: 10.1016/j.iac.2009.02.007 – volume: 2 start-page: 1 year: 2009 ident: 10.1016/j.biopsych.2010.12.006_bib23 article-title: Kynurenine pathway metabolites in humans: Disease and healthy states publication-title: Int J Tryptophan Res doi: 10.4137/IJTR.S2097 – volume: 134 start-page: 382 year: 1979 ident: 10.1016/j.biopsych.2010.12.006_bib41 article-title: A new depression scale designed to be sensitive to change publication-title: Br J Psychiatry doi: 10.1192/bjp.134.4.382 – volume: 56 start-page: 819 year: 2004 ident: 10.1016/j.biopsych.2010.12.006_bib7 article-title: Cytokines and psychopathology: Lessons from interferon-alpha publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2004.02.009 – volume: 22 start-page: 316 year: 2003 ident: 10.1016/j.biopsych.2010.12.006_bib38 article-title: Vascular factors and risk of dementia: Design of the Three-City Study and baseline characteristics of the study population publication-title: Neuroepidemiology doi: 10.1159/000072920 – volume: 59 start-page: 22 issue: suppl 20 year: 1998 ident: 10.1016/j.biopsych.2010.12.006_bib42 article-title: The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 publication-title: J Clin Psychiatry – volume: 933 start-page: 323 year: 2001 ident: 10.1016/j.biopsych.2010.12.006_bib59 article-title: Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.2001.tb05836.x – volume: 100 start-page: 159 year: 2005 ident: 10.1016/j.biopsych.2010.12.006_bib60 article-title: Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro publication-title: Immunol Lett doi: 10.1016/j.imlet.2005.03.008 – volume: 142 start-page: 127 year: 2007 ident: 10.1016/j.biopsych.2010.12.006_bib61 article-title: Vitamin C and E suppress mitogen-stimulated peripheral blood mononuclear cells in vitro publication-title: Int Arch Allergy Immunol doi: 10.1159/000096438 – volume: 176 start-page: 1299 year: 2007 ident: 10.1016/j.biopsych.2010.12.006_bib49 article-title: Sleep and aging: 1 publication-title: CMAJ doi: 10.1503/cmaj.060792 – volume: 39 start-page: 315 year: 1995 ident: 10.1016/j.biopsych.2010.12.006_bib43 article-title: The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue publication-title: J Psychosom Res doi: 10.1016/0022-3999(94)00125-O – volume: 32 start-page: 107 year: 2007 ident: 10.1016/j.biopsych.2010.12.006_bib33 article-title: Analysis of plasma biopterin levels in psychiatric disorders suggests a common BH4 deficit in schizophrenia and schizoaffective disorder publication-title: Neurochem Res doi: 10.1007/s11064-006-9233-5 – volume: 113 start-page: 372 year: 2006 ident: 10.1016/j.biopsych.2010.12.006_bib1 article-title: Prevalence and predictors of depression in populations of elderly: A review publication-title: Acta Psychiatr Scand doi: 10.1111/j.1600-0447.2006.00770.x – volume: 9 start-page: 622 year: 2008 ident: 10.1016/j.biopsych.2010.12.006_bib26 article-title: Chronic immune stimulation correlates with reduced phenylalanine turnover publication-title: Curr Drug Metab doi: 10.2174/138920008785821738 – volume: 1 start-page: 193 year: 2000 ident: 10.1016/j.biopsych.2010.12.006_bib27 article-title: Interferon-gamma-induced tryptophan degradation: Neuropsychiatric and immunological consequences publication-title: Curr Drug Metab doi: 10.2174/1389200003339063 – volume: 10 start-page: 668 year: 1991 ident: 10.1016/j.biopsych.2010.12.006_bib48 article-title: A comparison of fasting serum amino acid profiles of young and elderly subjects publication-title: J Am Coll Nutr doi: 10.1080/07315724.1991.10718185 – volume: 15 start-page: 393 year: 2010 ident: 10.1016/j.biopsych.2010.12.006_bib37 article-title: CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: Relationship to CNS immune responses and depression publication-title: Mol Psychiatry doi: 10.1038/mp.2009.116 – volume: 344 start-page: 961 year: 2001 ident: 10.1016/j.biopsych.2010.12.006_bib20 article-title: Paroxetine for the prevention of depression induced by high-dose interferon alfa publication-title: N Engl J Med doi: 10.1056/NEJM200103293441303 – year: 2007 ident: 10.1016/j.biopsych.2010.12.006_bib18 – volume: 663 start-page: 490 year: 1992 ident: 10.1016/j.biopsych.2010.12.006_bib10 article-title: Increased cytokine production by peripheral blood mononuclear cells from healthy elderly people publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.1992.tb38712.x – volume: 13 start-page: 561 year: 1995 ident: 10.1016/j.biopsych.2010.12.006_bib44 article-title: Treatment of neurotoxic side effects of interferon-alpha with naltrexone publication-title: Cancer Invest doi: 10.3109/07357909509024923 – volume: 27 start-page: 24 year: 2006 ident: 10.1016/j.biopsych.2010.12.006_bib6 article-title: Cytokines sing the blues: Inflammation and the pathogenesis of depression publication-title: Trends Immunol doi: 10.1016/j.it.2005.11.006 – volume: 37 start-page: 684 year: 2004 ident: 10.1016/j.biopsych.2010.12.006_bib47 article-title: Increasing production of homocysteine and neopterin and degradation of tryptophan with older age publication-title: Clin Biochem doi: 10.1016/j.clinbiochem.2004.02.007 – volume: 29 start-page: 57 year: 1994 ident: 10.1016/j.biopsych.2010.12.006_bib30 article-title: Changes in plasma tetrahydrobiopterin levels of depressives in depressive and remission phases: Reconfirmed by measurement with an internal standard publication-title: Neuropsychobiology doi: 10.1159/000119064 – volume: 102 start-page: 1390 year: 2009 ident: 10.1016/j.biopsych.2010.12.006_bib21 article-title: Vitamin E status and quality of life in the elderly: Influence of inflammatory processes publication-title: Br J Nutr doi: 10.1017/S0007114509990493 – volume: 1199 start-page: 1 year: 2010 ident: 10.1016/j.biopsych.2010.12.006_bib46 article-title: Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.2009.05356.x – volume: 128 start-page: 92 year: 2007 ident: 10.1016/j.biopsych.2010.12.006_bib12 article-title: Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans publication-title: Mech Ageing Dev doi: 10.1016/j.mad.2006.11.016 – volume: 9 start-page: 1498 year: 2003 ident: 10.1016/j.biopsych.2010.12.006_bib56 article-title: Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation publication-title: Nat Med doi: 10.1038/nm954 – volume: 908 start-page: 244 year: 2000 ident: 10.1016/j.biopsych.2010.12.006_bib11 article-title: Inflamm-aging publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.2000.tb06651.x – volume: 19 start-page: 1329 year: 2005 ident: 10.1016/j.biopsych.2010.12.006_bib8 article-title: Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system publication-title: FASEB J doi: 10.1096/fj.05-3776fje – year: 2010 ident: 10.1016/j.biopsych.2010.12.006_bib52 article-title: The 5-HTTLPR polymorphism and eating disorders: A meta-analysis publication-title: Int J Eat Disord – reference: 21708303 - Biol Psychiatry. 2011 Jul 15;70(2):111-2 |
| SSID | ssj0007221 |
| Score | 2.520313 |
| Snippet | Neuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental characteristic of... Background Neuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental... *BACKGROUND : Neuropsychiatric symptoms are common complaints of elderly persons. Recent data suggest that chronic low-grade inflammation, a fundamental... |
| SourceID | hal proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 175 |
| SubjectTerms | Aged Aged, 80 and over Aging Biological and medical sciences C-Reactive Protein - metabolism Chronic Disease enzymatic pathways Enzyme-Linked Immunosorbent Assay - methods Fasting Fatigue - blood Fatigue - etiology Female Geriatrics Humans Indoleamine-Pyrrole 2,3,-Dioxygenase - blood inflammation Inflammation - blood Inflammation - complications Interleukin-6 - blood Life Sciences Male Medical sciences Mental Disorders - blood Mental Disorders - etiology Movement Disorders Neopterin - blood neuropsychiatric symptoms Nitrites - blood Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sleep Wake Disorders - blood Sleep Wake Disorders - etiology tryptophan Tryptophan - blood tyrosine Tyrosine - blood |
| Title | Chronic Low-Grade Inflammation in Elderly Persons Is Associated with Altered Tryptophan and Tyrosine Metabolism: Role in Neuropsychiatric Symptoms |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0006322310012783 https://www.clinicalkey.es/playcontent/1-s2.0-S0006322310012783 https://dx.doi.org/10.1016/j.biopsych.2010.12.006 https://www.ncbi.nlm.nih.gov/pubmed/21277567 https://www.proquest.com/docview/874184845 https://hal.inrae.fr/hal-02646644 |
| Volume | 70 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELfGEB8SQlAGhI_KQrxmjR3bSXirqo0W1glBkfZm2YkjOrVJ1XSgvvBH8Bdzl4-OCRAIHhP5Ett3OV_su9-PkJdGRokMAweRmxW-kCbwbaSEnyY2SW0cZNJhNfL0VI0_ijdn8myPjLpaGEyrbH1_49Nrb93eGbSzOVjN51jjC8srx_gEj09jRPwUIkIrP_x6meYRcd6y5ikfW_9QJXx-aOdlnVTcpHjhtiAyH_16gbr2CTMl76xMBZOXN6wXvw9L6-Xp-B6528aVdNh0_T7Zc0WP3GiYJrc9cmvUEbv1yM1pe57-gHxrsXHpSfnFf702maOTIgcjaQoa6bygR0jjvdjSd3VoXtFJRTuVuoziNi4d4ok7XMzW2xXiFJiCmgIutzBAeA2dug2Y2mJeLV_R9-XC4WNrUJBdqjX04MN2CcLL6oDMjo9mo7HfsjT4qRRs46dKmcAKFsehcioL4pxl3DkW2RxmVaUmFAgZzzgzAoKPNM1Vwi1XVigLziR8SPaLsnCPCZVRCPGXQ8g0KUwsDDjxOIlzjihXCUs8IjvN6LRFMEcijYXuUtXOdadRjRrVjGvQqEcGO7lVg-HxR4moU7zuKlTBp2pYZv5N0lWta6g00xW01D-Zr0eSneSVL-Cv3voCrHM3OIQMHw9PNN6Df2xkEBCfmUf6V4x315xjdXGguEdoZ80aTBJPjkzhyotKx4hxJGIhPfKosfJLYeh8JFX05D-6_5TcbrbqI5_JZ2R_s75wzyHW29h-_TH3yfXh5O349Ds0eFIh |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1tb9MwED5tnWBICEEZW3gZFuJraF5sJ-FbVW20rK0QFGnfLDt1RKc2rZoO1L_BL-aueYEJEAg-xsolju98vth3zwPwUosoEaFnMXIz3OVCe66JJHfTxCSpib2psFSNPBrL_kf-9lJc7kGvroWhtMrK95c-feetq5ZONZqd1WxGNb64vAYUn9DxaRzuwwGhU4kWHHQHF_1x45CjIKiI86RLAj8UCl-9MrPlLq-4zPKinUEiP_r1GrX_iZIl7650geOXlcQXv49MdyvU-X24V4WWrFv2_gHs2bwNt0qyyW0bDns1t1sbbo-qI_WH8LWCx2XD5Rf3zVpPLRvkGdpJWdPIZjk7Iybv-Za920XnBRsUrNaqnTLayWVdOnTHi8l6uyKoAp0znePlFj8QX8NGdoPWNp8Vi9fs_XJu6bE7XJAm2xp78GG7QOFFcQST87NJr-9WRA1uKri_cVMptWe4H8ehtHLqxZk_Daz1I5PhqMpUh5xQ4_3A1xzjjzTNZBKYQBouDfqT8BG08mVuT4CJKMQQzBJqmuA65hr9eJzEWUBAV4mfOCBqzai0AjEnLo25qrPVrlStUUUaVX6gUKMOdBq5VQnj8UeJqFa8qotU0a0qXGn-TdIWlXcolK8KvFP9ZMEOJI3kjUnwV299gdbZfByhhve7Q0Vt-JtNJAL8s-_A6Q3jbW4PqMDYk4EDrLZmhSZJh0c6t8vrQsUEc8RjLhw4Lq38uzB2PhIyevwf3X8Oh_3JaKiGg_HFE7hT7txHri-eQmuzvrbPMPTbmNNqan8DohtU0g |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chronic+Low-Grade+Inflammation+in+Elderly+Persons+Is+Associated+with+Altered+Tryptophan+and+Tyrosine+Metabolism%3A+Role+in+Neuropsychiatric+Symptoms&rft.jtitle=Biological+psychiatry+%281969%29&rft.au=CAPURON%2C+Lucile&rft.au=SCHROECKSNADEL%2C+Sebastian&rft.au=FEART%2C+Catherine&rft.au=AUBERT%2C+Agn%C3%A8s&rft.date=2011-07-15&rft.pub=Elsevier&rft.issn=0006-3223&rft.eissn=1873-2402&rft.volume=70&rft.issue=2&rft.spage=175&rft.epage=182&rft_id=info:doi/10.1016%2Fj.biopsych.2010.12.006&rft.externalDBID=n%2Fa&rft.externalDocID=24343062 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00063223%2FS0006322311X00124%2Fcov150h.gif |