Strengths and weaknesses of pneumococcal conjugate vaccines

• Published in: Glycoconjugate journal Vol. 40; no. 2; pp. 135 - 148
• Main Authors: Micoli, Francesca, Romano, Maria Rosaria, Carboni, Filippo, Adamo, Roberto, Berti, Francesco
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2023; Springer Nature B.V
• Subjects: Antibodies, Bacterial; Antigens; Bacterial infections; Biochemistry; Biomedical and Life Sciences; Drug resistance; Ear diseases; Epidemiology; Humans; Life Sciences; Mini Review; Pathology; Penicillin; Pneumococcal Infections - epidemiology; Pneumococcal Infections - prevention & control; Pneumococcal Vaccines - therapeutic use; Pneumonia; Polysaccharides; Proteins; Serotypes; Streptococcus infections; Streptococcus pneumoniae; Vaccination; Vaccines; Vaccines, Conjugate - therapeutic use; Virulence; Bacterial infection; Vaccine; Conjugate; Polysaccharide; Streptococcus pneumoniae

Multivalent vaccines addressing an increasing number of Streptococcus pneumoniae types (7-, 10-, 13-, 15-, 20-valent) have been licensed over the last 22 years. The use of polysaccharide-protein conjugate vaccines has been pivotal in reducing the incidence of invasive pneumococcal disease despite th...