Nerve growth factor receptor limits inflammation to promote remodeling and repair of osteoarthritic joints

• Published in: Nature communications Vol. 15; no. 1; pp. 3225 - 16
• Main Authors: Zhao, Lan, Lai, Yumei, Jiao, Hongli, Huang, Jian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/100; 13/109; 13/21; 13/44; 13/51; 13/95; 14/19; 14/63; 38; 38/77; 38/88; 38/91; 42; 45; 49; 59; 631/80/304; 631/80/86/2368; 64; 64/60; 692/4023/1670/407; Animals; Arthritis; Bone growth; Bone resorption; Cartilage diseases; Cartilage, Articular - metabolism; Cells (biology); Clinical trials; Growth factors; Humanities and Social Sciences; Humans; Inflammation; Joint diseases; Joints (anatomy); Joints - metabolism; Mice; multidisciplinary; Nerve growth factor; Nerve Growth Factor - metabolism; Nerve growth factor receptors; Nerves; NF-kappa B; NF-κB protein; Osteoarthritis; Osteogenesis; Osteophytes; Progenitor cells; Receptor, Nerve Growth Factor; Receptors; Receptors, Nerve Growth Factor; Science; Science (multidisciplinary); Subchondral bone

Osteoarthritis (OA) is a painful, incurable disease affecting over 500 million people. Recent clinical trials of the nerve growth factor (NGF) inhibitors in OA patients have suggested adverse effects of NGF inhibition on joint structure. Here we report that nerve growth factor receptor (NGFR) is upr...