In-tube micro-pyramidal silicon nanopore for inertial-kinetic sensing of single molecules

• Published in: Nature communications Vol. 15; no. 1; pp. 5132 - 12
• Main Authors: Yang, Jianxin, Pan, Tianle, Xie, Zhenming, Yuan, Wu, Ho, Ho-Pui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.06.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/57; 639/925/927/1058; 9/10; Centrifugal force; Conformation; Dwell time; Electrochemistry; Humanities and Social Sciences; Inertial sensing devices; multidisciplinary; Photovoltaics; Plasma etching; Pore size; Proteins; Science; Science (multidisciplinary); Sensitivity; Signal to noise ratio; Silicon; Silicon wafers; Translocation

Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in non-uniform conductance signals with low conformational sensitivity, which hinders the acc...